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. 2020 May 6;11:2222. doi: 10.1038/s41467-020-15786-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Surveys 1–7 spanned a time of 3.6–7.1 years after the 12 November 2011 introduction of PCV into Malawi’s EPI program. Younger children (4–8 weeks up to 2 years of age; cells a–c) were recruited starting survey 4 or 5. Prevalence of non-carriers is calculated by 1 − (NVT + VT). Aggregated sample size for each study group: a n = 346 children 4–8 weeks old (PCV-unvaccinated), b n = 566 children 18 weeks to 1 year old (PCV vaccinated), c n = 499 children 2 years old (PCV vaccinated), d n = 2565 children 3–7 years old (PCV vaccinated), e n = 1402 children 3–10 years old (PCV-unvaccinated), f n = 1770 HIV-infected adults on ART (PCV-unvaccinated). Refer to Supplementary Tables 3 and 4 for the sample sizes used in calculating per-survey VT and NVT prevalence data and error bars in this figure. 95% confidence interval error bars are shown. The confidence interval bounds are calculated by exponentiating the bounds in the logit scale.