TABLE 2.

Combination index and dose reduction values for entry inhibition of Zaire-PsV infection by combining tolcapone with entry-inhibitory antivirals in semen.

Drug combination, %Inhibitory Conc. (Molar ratio)	CIa	Tolcapone			Entry-inhibitory antivirals
		IC50(nM)b		Dose reduction	IC50(nM)b		Dose reduction
		Alone Mixture		(Fold)	Alone Mixture		(Fold)
Tolcapone:Bepridil (133:1)
50	0.372	2637.62	915.67	2.88	279.74	6.87	40.72
90	0.216	29044.10	5619.65	5.17	1844.83	42.15	43.77
Tolcapone:Sertraline (100:1)
50	0.151	2637.62	356.26	7.40	219.63	3.56	61.69
90	0.534	29044.10	13009.00	2.23	1514.23	130.09	11.64

^aCI, combination index. ^bData are the means of two independent experiments performed in triplicate.