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Cytotoxicity in vitro and selective index values of tolcapone against all tested cellsa.
| Cell lines | Category | CC50 (μM) | IC50 (μM) | SI |
| HeLa | Reproductive cancer cells | 292.6 ± 41.6 | 2.99 ± 1.33 | 97.86 |
| A549 | Lung carcinoma cells | 266.1 ± 34.3 | 4.33 ± 2.26 | 61.45 |
| THP-1 | Human macrophages | 169.3 ± 14.5 | 3.24 ± 0.78 | 52.25 |
| HuH-7 | Hepatoma cells | 324.8 ± 48.8 | 3.29 ± 0.99 | 98.72 |
aThe assay was performed in triplicate; Data are presented as the mean ± SD.
