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. 2020 May 6;6:12. doi: 10.1038/s41540-020-0131-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 11 — a Histogram (top left) shows the distribution of palindrome size in gga-miR_HR region. Box plot (top right) shows ΔG for miR-4673/gga-miR_HR hybridisation. The gga-miR_HR genes are central to several developmental signalling networks interfacing at Wnt cascade. Amongst gga-miR_HR genes several NPS from the Wnt cascade nearly achieved structural features of functional miRNAs. b Application of miR-4673 and activation of the identified gga-miR_HR shadow interactome boosted angiogenic activity in chorio-allantoic membrane (top). Blue pseudo-colourised elements demonstrate expansion of microvessels (black arrow) along with increased hematopoiesis. The miRNA also amplified hematopoiesis (red pseudo-colour) and neurogenesis (black arrows) in the explanted embryo (frontal cortex: white arrow) (error bars: s.d; ** indicates p < 0.01).