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. 2020 May 6;6:12. doi: 10.1038/s41540-020-0131-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Genomic distribution of miR-4673 interactome shows distinct gene clusters localised to H3⁺ isochores (middle circular diagram). The miRNA homology regions (miR_HR) were scattered in coding sequences (inner karyogram genes in black), 5′e-UTRs (inner karyogram genes in red), 3′e-UTRs (inner karyogram genes in green) and i-UTRs of human genes (outer karyogram). Sense and anti-sense directionality of (miR_HR) in the inner karyogram is designated as + and −. In the outer karyogram red circles indicate the genes with miR_HR in antisense direction to miR-4673. Genes with miR_HR signature are involved in regulating development of cardiovascular and nervous systems (inner diagram). These genes act as calibrators (tissue-specific modulators) of Wnt signalling by fine-tuning canonical and non-canonical modules of the cascade (see Supplementary Discussion 1 for detailed elaboration). The outer colour-coded layer designates the interactome genes to canonical Wnt and non-canonical Wnt/Ca²⁺, Wnt/PCP (planar cell polarity), Wnt/Autophagy (A.P.) and Wnt/Mitosis cascades.