Fig. 1.

Cocoa for pain relief. The figure resumes all the putative mechanisms involved in the anti-inflammatory and anti-nociceptive effects of cocoa by compounds: polyphenols [23–29], methylxanthines [32, 33], N-acylethanolamines [34–36], biogenic amines [36–38], alkaloids [39–42], and tryptophan [43–48]