Table 3.
Adjusted mean (SE) POMWP AUC(0–72h) (cm) ANCOVA analysis—treated set (TS)
| Treatment | N | Mean (SD) at baseline | Adjusted mean (SE)a | Comparison vs. diclofenac + capsaicin | ||
|---|---|---|---|---|---|---|
| Adjusted mean of difference (SE)a,b | 95% CI | P value | ||||
| Placebo | 75 | 7.20 (1.246) | 3.92 (0.230) | − 0.50 (0.238) | − 0.97, − 0.04 | 0.0347 |
| Capsaicin | 223 | 7.22 (1.157) | 3.10 (0.156) | 0.32 (0.169) | − 0.02, 0.65 | 0.0622 |
| Diclofenac | 223 | 7.29 (1.274) | 4.10 (0.156) | − 0.68 (0.169) | − 1.01, − 0.35 | < 0.0001 |
| Diclofenac + capsaicin | 225 | 7.28 (1.148) | 3.41 (0.154) | |||
aModel includes treatment, country, application site, and baseline POMWP
bNegative values are in favour of the combination treatment