Table 6.
Adjusted mean (SE) for change from baseline in pressure algometry (N/cm2) at day 6 morning—TS
| Treatment | N | Mean (SD) at baseline | Adjusted mean (SE)a | Comparison vs. diclofenac + capsaicin | ||
|---|---|---|---|---|---|---|
| Adjusted mean of difference (SE)a,b | 95% CI | P value | ||||
| Placebo | 75 | 16.03 (5.162) | 8.01 (1.199) | 1.65 (1.339) | − 0.98, 4.27 | 0.2193 |
| Capsaicin | 223 | 15.47 (5.456) | 9.38 (0.737) | 0.28 (0.949) | − 1.58, 2.15 | 0.7672 |
| Diclofenac | 223 | 15.61 (5.379) | 7.64 (0.740) | 2.02 (0.950) | 0.15, 3.88 | 0.0339 |
| Diclofenac + capsaicin | 225 | 15.73 (5.378) | 9.66 (0.737) | |||
CI confidence interval, SD standard deviation, SE standard error, TS treated set
aModel includes treatment, country, application site, time, treatment by time interaction, baseline pressure algometry and baseline pressure algometry by time interaction
bPositive values are in favor of the combination treatment