Table 5.
Antiprotozoal activity (IC50) and toxicity to mammalian cells (SI) of the crude extract from the fungus, Phyllosticta capitalensis
| Cells | IC50 (μg/mL) | SI(a,b,c) |
|---|---|---|
| Leishmania amazonensis | 17.2 ± 0.5 | 7.9(a) |
| Leishmania infantum | 82 ± 5.7 | 1.6(b) |
| Trypanosoma cruzi | 50.1 ± 12.7 | 1.1(c) |
| Fibroblast L929 | 135.9 ± 29.1 | - |
| Epitelial LLCMK2 | 55.9 ± 8.3 | - |
IC50, inhibitory concentration for 50% of the parasites; CC50, cytotoxic concentration for 50% of mammalian cells; SI, selectivity index; SI(a), selectivity index in promastigote forms of Leishmania amazonensis (CC50 in L929/IC50); SI(b), selectivity index in promastigote forms of Leishmania infantum (CC50 in L929/IC50); SI(c), selectivity index in epimastigote forms of Trypanosoma cruzi (CC50 in LLCMK2/IC50)