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. 2020 Feb 15;9(1):113–128. doi: 10.1007/s40122-020-00155-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — a Reduction in mean VAS score (pooled data) [68]. b Reduction in mean VAS score in subgroup [68]. c Reduction in WOMAC score in AFOA and total HAQ score for pain in AFRA [68]. *All p < 0.05 for tramadol + diclofenac vs. tramadol + paracetamol. VAS Visual Analog Scale, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index, AFOA Acute Flare-up of Osteoarthritis, HAQ Health Assessment Questionnaire, AFRA Acute Flare-up of Rheumatoid Arthritis, AMSP Acute Musculoskeletal Pain, POP Postoperative Pain