Table 1.
Summary of RCTs of RA and RAS for IPF.
| Study year[ref] | Country | Sample size (Experimental/Control) | Mean age (years) (Experimental/Control) | Experimental | Control | Duration |
|---|---|---|---|---|---|---|
| Sun XS 2005 (Sun, 2005) | China | 60(30/30) | 61.10 ± 12.88/66.67 ± 7.70 | QiHong Decoction | Prednisone tablet | 3 months |
| Wei GS 2007 (Wei and Qiang, 2007) | China | 54(36/18) | 40-78(58.4)/38-74(55.2) | CWMT + Prednisone tablet + TongFeiHuoXue Decoction | CWMT + Prednisone tablet | 1 month |
| Sun ZT 2008 (Sun et al., 2008) | China | 30(15/15) | 56.45 ± 7.88/56.88 ± 9.76 | Prednisone tablet + YiQiHuoXueSanJie Basic Prescription | Prednisone tablet | 3 months |
| Dong H 2010 (Dong, 2010) | China | 66(33/33) | 59.11 ± 11.18/57.7 ± 10.4 | Prednisone tablet + KangXianShuFei Granules | Prednisone tablet | 3 months |
| Yang ZJ 2010 (Yang, 2010) | China | 40(20/20) | 60.4 ± 8.61/60.25 ± 8.72 | YiQiYangYin Prescription | Prednisone tablet | 3 months |
| Wang F 2011 (Wang, 2011) | China | 28(14/14) | 52.3 ± 3.6/54.5 ± 4. 6 | Prednisone tablet + KangXianShuFei Chinese Medicine | Prednisone tablet | 6 months |
| Chen P 2012 (Chen et al., 2012) | China | 50(25/25) | 55-72(63)/53-74(65) | CWMT + HuaXianPoGu Decoction | CWMT | 3 months |
| Wu HS 2012 (Wu et al., 2012) | China | 71(36/35) | 41-76(62.5)/42-79(63.4) | CWMT + Prednisone tablet + Cyclophosphamide tablet + KangYangHuaXianRuanFei Magical Prescription | CWMT + Prednisone tablet + Cyclophosphamide tablet | 6 months |
| Meng Y 2016 (Meng et al., 2016) | China | 80(40/40) | 63.52/n.r. | Prednisone tablet + Cyclophosphamide tablet + YiQiYangXue Chinese Medicine Decoction | Prednisone tablet + Cyclophosphamide tablet | 2 months |
| Zhao YD 2016 (Zhao et al., 2016) | China | 120(60/60) | 55.17 ± 13.13/57.26 ± 10.14 | CWMT + N-acetylcysteine tablet + BuFeiHuoXueHuaPi Prescription | CWMT + N-acetylcysteine tablet | 12 months |
| Jiang WZ 2017 (Jiang, 2017) | China | 80(40/40) | 65.58 ± 3.35/65.62 ± 3.40 | CWMT + Prednisone tablet + YiQiHuoTanZhuYu Chinese Medicine Prescription | CWMT + Prednisone tablet | 40 days |
| Miao G 2018 (Miao et al., 2018) | China | 80(40/40) | 67.4 ± 4.7/66.3 ± 4.8 | CWMT + Prednisone tablet + cyclophosphamide + YiQiYangYinSanJieHuaTan Prescription | CWMT + Prednisone tablet + Cyclophosphamide tablet | 2 months |
| Yang QM 2018 (Yang, 2018) | China | 82(41/41) | 67.16 ± 7.84/67.56 ± 7.14 | CWMT + Prednisone tablet + YiQiHuoTanZhuYu Decoction | CWMT + Prednisone tablet | 1 month |
| Ma Q 2018 (Ma, 2018) | China | 72(36/36) | 67.93 ± 8.49/69.17 ± 7.98 | CWMT + Echinocysteine effervescent tablet + BuYangHuanWu Decoction and LiuJunZi Decoction | CWMT + Acetylcysteine effervescent tablet | 12 weeks |
| Deng F 2018 (Deng and Wang, 2018) | China | 118(59/59) | 64.06 ± 7.82/63.21 ± 7.45 | CWMT + Prednisone tablet + HuangQiTaoHong Decoction | CWMT + Prednisone tablet | 3 months |
| Guo SJ 2019 (Guo et al., 2019) | China | 130(65/65) | 59.45 ± 5.19/58.62 ± 5.02 | CWMT + QiZhuKangXian Granules | CWMT + placebo | 48 weeks |
| Peng YF 2019 (Peng, 2019) | China | 50(25/25) | 58.96 ± 8.73/59.80 ± 9. 34 | CWMT + Prednisone tablet + QiGui Prescription | CWMT + Prednisone tablet | 12 weeks |
RCT, randomized controlled trial; RA, Radix Astragali; RAS, Radix Angelicae Sinensis; IPF, Idiopathic pulmonary fibrosis; CWMT, conventional western medicine treatment; n.r., not reported.