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. 2020 Apr 30;11:479. doi: 10.3389/fphar.2020.00479

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Copyright © 2020 Árpádffy-Lovas, Baczkó, Baláti, Bitay, Jost, Lengyel, Nagy, Takács, Varró and Virág

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of the sodium channel inhibitor mexiletine (panel A) and the L-type calcium current blocker nisoldipine (panel B) on the human electrical restitution curve. The data points up to 1000 ms diastolic interval were fitted by single exponential function. The inset shows the kinetical time constants in control conditions and after drug application. On the right part of the figure original action potential traces are shown before and after drug application at basic cycle length of 1000 ms.