Fig. 1. Comparison of profiles of lipid mediators (LMs) derived from COX-1/2, 5-LO, 12/15-LO, and P450 products of arachidonic acid (AA) from patients with rheumatoid arthritis (RA) or osteoarthritis (OA). (A) Profiles of LMs derived from COX-1/2, 5-LO, 12/15-LO, and P450 products of AA in synovial fluid (SF) from patients with RA, compared with those in SF from patients with OA. The concentration (area under the curve/mL) ratios (RA/OA) are shown. (B) Comparison of concentrations of LMs derived from COX-1/2, 5-LO, 12/15-LO, and P450 products of AA. The data are shown as a box-plot. The concentrations of LMs are shown as pmol/mL. p values are shown. COX, cyclooxygenase; DHETE, dihydroxyeicosatrienoic acid; DiHETE, dihydroxyeicosatrienoic acid; EET, epoxyeicosatrienoic acids; ETE, eicosatetraenoic acid; HETE, hydroxyeicosatetraenoic acid; HHT, hydroxyheptadecatrienoic acid; HpETE, hydroperoxyeicosatetraenoic acid; LT, leukotriene; LO, lipoxygenase; LX, lipoxin; P450, cytochrome p450; PG, prostaglandin; Tx, thromboxane.