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In vitro and in vivo toxicity of lipid nanostars (LNSs). The cell viability of HepG2 cells treated with different concentrations of the LNSs (A). The serum biochemistry examination of the mice injected with 10 mg of lipid nanoparticles (LNPs) and LNSs (B). The HE staining of the major organs of the mice injected with 10 mg of LNPs and LNSs (C). *p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.001, compared with PBS group.
