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. 2020 May 6;5(3):e00190-20. doi: 10.1128/mSphere.00190-20

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Copyright © 2020 Brauer et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — A. flavus EVs induce a protective effect on Galleria mellonella in an in vivo model. (A) G. mellonella larvae (n = 5 per group) were stimulated with A. flavus EVs (10⁵, 10⁶, and 10⁷ particles) or with PBS as a control 48 h prior to infection with A. flavus conidia. Larvae were homogenized and levels of CFU content determined 48 h postinfection for fungal burden analysis. (B) Survival rates (n = 5 larvae per group) during 15 days postinfection. Data represent the results of two independent experiments. One-way ANOVA and Bonferroni’s multiple-comparison tests were used for fungal burden analysis and the log rank (Mantel-Cox) test for survival curve analysis. *, P < 0.05.