FIG 1.
Manhattan plot (A) and QQ plot (B) showing the significance of SNP rs2516513 associated with drug-induced reduction on rCDI in the GWAS analysis (placebo arm versus bezlotoxumab and bezlotoxumab + actoxumab arms). λGC is 1.06 in the QQ plot. Open triangles represent the assayed SNPs; solid symbols represent the imputed SNPs. The dotted line is the genome-wide significance P value threshold of 5 × 10−08. GWAS, genome-wide association study; rCDI, recurrent Clostridium difficile infection; SNP, single nucleotide polymorphism.