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. 2020 Apr 30;10:638. doi: 10.3389/fonc.2020.00638

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Copyright © 2020 Yuan, Chen, Wang, Xu, Zhang, Sun and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of the hub genes is downregulated in CRC. According to the qPCR results, HCLS1 (A,D), EVI2B (B,E), and CD48 (C,F) are downregulated in CRC tissues and cells. *P < 0.05.