Table 1.
Genetic alterations on the same chromosomal location common to at least three tumors.
| Chromosome cytoband start location | Types of alteration in tumor | ||||
|---|---|---|---|---|---|
| Tumor 1 | Tumor 2 | Tumor 3 | Tumor 4 | Tumor 5 | |
| 1q31.1 | – | LOH | – | Gain | Gain |
| 3p26.3 (26, 27) | – | – | Loss | Loss | Loss |
| 4q31.2 | – | – | Loss | Gain | Gain |
| 4q35.1 (FAT1) (1, 31) | – | – | Loss | Loss | Gain |
| 5q11.2 | Loss | – | – | Loss | Loss |
| 6p25.2 | LOH | – | Gain | Gain | LOH |
| 7p11.2 (EGFR) (1, 31) | – | – | Gain | Gain | Gain |
| 9p23 | LOH | Gain | Gain | Loss | LOH |
| 11q13.3 (CCND1, FADD, CTTN) (1) | Gain | – | Gain | – | Gain |
| 12q24.12 (ALDH2) | LOH | LOH | – | Gain | – |
| 13q13.1 | Loss | – | – | LOH | Loss |
| 15q11.2 | Gain | – | Loss | Loss | Gain |
| 16p13.3 | LOH | – | Loss | Gain | Gain |
| 17p13.2 (TP53) (1, 31) | LOH | – | – | LOH | Gain + LOH |
| 20q11.21 | Gain | – | Gain | – | Gain |
| 22q11.23 (GSTT1) | – | – | Gain | Gain | Gain |
The same chromosomal location revealed intertumoral genetic diversity of all five tumors based on either (a) a discrepancy in the genetic alterations (gain, loss, or LOH) or (b) the presence/absence of a genetic alteration only in certain tumors.