Table 10.
Pharmacokinetic parameters of GABA in blood and brain dialysate after administration of NAG (75, 150, 300 mg/kg) and GHI (10 ml/kg) (mean ± S.D., n = 6).
| Parameters | Unit | NAG-L | NAG-M | NAG-H | GHI |
|---|---|---|---|---|---|
| blood | |||||
| Cmax | μg/ml | 14.15 ± 1.86 | 35.48 ± 3.26 | 46.25 ± 7.57 | 37.25 ± 3.04 |
| Tmax | min | 186.67 ± 11.55 | 173.33 ± 11.54 | 208 ± 62.61 | 153.33 ± 11.55 |
| AUC0-t | min μg/ml | 2,439.22 ± 297.17 | 5,984.99 ± 269.87 | 8,211.13 ± 996.86 | 9,257.38 ± 713.92 |
| AUC0-∞ | min μg/ml | 4,603.47 ± 381.58 | 7,362.57 ± 204.04 | 11,932.80 ± 369.29 | 22,111.95 ± 2,652.87 |
| T1/2 | min | 155.05 ± 5.79 | 84.21 ± 7.21 | 143.69 ± 12.41 | 311.12 ± 2.68 |
| MRT | min | 232.16 ± 9.95 | 245.38 ± 7.78 | 285.15 ± 38.46 | 541.11 ± 6.53 |
| brain | |||||
| Cmax | μg/ml | 98.39 ± 10.74 | 174.94 ± 16.70 | 114.63 ± 11.03 | 244.89 ± 13.17 |
| Tmax | min | 200 | 200 | 200 | 200 |
| AUC0-t | min μg/ml | 5,192.49 ± 475.31 | 14,060.00 ± 407.05 | 12,939.70 ± 765.62 | 9,502.58 ± 823.02 |
| AUC0-∞ | min μg/ml | 5,533.03 ± 506.78 | 16,025.80 ± 1518.08 | 21,640.60 ± 1785.04 | 10,132.60 ± 879.29 |
| T1/2 | Min | 46.46 ± 5.58 | 83.82 ± 6.56 | 164.25 ± 14.99 | 65.93 ± 9.02 |
| MRT | Min | 205.52 ± 16.04 | 207.42 ± 25.71 | 328.15 ± 22.35 | 198.30 ± 3.05 |
| AUCbrain/A | — | 212.88 ± 46.80 | 234.92 ± 9.21 | 157.59 ± 26.89 | 102.65 ± 10.56 |
| AUCblood/% | |||||