Table 8.
Pharmacokinetic parameters of NAG in blood and brain dialysate after administration of NAG (75, 150, 300 mg/kg) and GHI (10 ml/kg) (mean ± S.D., n = 6).
| Parameters | Unit | NAG-L | NAG-M | NAG-H | GHI |
|---|---|---|---|---|---|
| blood | |||||
| Cmax | μg/ml | 74.35 ± 4.40 | 118.61 ± 6.67 | 128.25 ± 6.24 | 118.37 ± 6.50 |
| Tmax | min | 20 | 20 | 20 | 20 |
| AUC0-t | min μg/ml | 5,974.85 ± 308.14 | 9,912.29 ± 279.02 | 13,231.38 ± 879.57 | 12,513.72 ± 1076.02 |
| AUC0-∞ | min μg/ml | 5,995.84 ± 307.47 | 9,930.36 ± 276.77 | 13,296.37 ± 912.14 | 12,585.28 ± 1088.65 |
| T1/2 | min | 44.15 ± 3.19 | 38.30 ± 6.89 | 30.23 ± 11.86 | 45.33 ± 13.44 |
| MRT | min | 56.06 ± 1.73 | 56.65 ± 2.42 | 74.24 ± 4.03 | 77.43 ± 3.75 |
| brain | |||||
| Cmax | μg/ml | 7.76 ± 0.50 | 30.57 ± 3.33 | 53.44 ± 4.71 | 41.48 ± 3.34 |
| Tmax | min | 40 | 40 | 40 | 40 |
| AUC0-t | min μg/ml | 835.63 ± 22.90 | 2,719.18 ± 126.95 | 4,584.42 ± 233.23 | 3,772.27 ± 235.01 |
| AUC0-∞ | min μg/ml | 978.10 ± 58.06 | 2,754.50 ± 122.00 | 4,644.40 ± 233.96 | 4,016.83 ± 420.52 |
| T1/2 | Min | 120.35 ± 17.88 | 57.80 ± 3.35 | 57.39 ± 6.03 | 74.81 ± 14.84 |
| MRT | Min | 170.61 ± 24.99 | 86.37 ± 1.81 | 73.60 ± 3.35 | 73.60 ± 3.35 |
| AUCbrain/A | — | 13.99 ± 0.6 | 27.43 ± 1.47 | 34.81 ± 3.65 | 34.81 ± 3.65 |
| AUCblood/% | |||||