Table 9.
Pharmacokinetic parameters of Glu in blood and brain dialysate after administration of NAG (75, 150, 300 mg/kg) and GHI (10 ml/kg) (mean ± S.D., n = 6).
| Parameters | Unit | NAG-L | NAG-M | NAG-H | GHI |
|---|---|---|---|---|---|
| blood | |||||
| Cmax | μg/ml | 5,566.33 ± 1,102.14 | 9,999.94 ± 975.78 | 17,499.67 ± 1,605.09 | 17,999.53 ± 1,541.07 |
| Tmax | min | 200 ± 20 | 140 ± 22.95 | 192 ± 33.47 | 130 ± 27.57 |
| AUC0-t | min μg/ml | 1,077.47 ± 71.02 | 2,194.84 ± 122.12 | 4,078.53 ± 246.03 | 4,411.36 ± 533.31 |
| AUC0-∞ | min μg/ml | 1,188.00 ± 98.42 | 2,654.84 ± 213.90 | 4,934.92 ± 395.20 | 7,578.10 ± 735.28 |
| T1/2 | min | 64.04 ± 1.82 | 108.84 ± 5.21 | 86.50 ± 8.89 | 279.40 ± 17.83 |
| MRT | min | 198.27 ± 9.67 | 223.43 ± 12.27 | 237.12 ± 16.18 | 529.41 ± 26.11 |
| brain | |||||
| Cmax | μg/ml | 940.73 ± 95.22 | 15,416.29 ± 1,170.58 | 11,275.20 ± 895.12 | 1,206.82 ± 91.39 |
| Tmax | min | 200 | 200 | 200 | 200 |
| AUC0-t | min μg/ml | 118.76 ± 6.33 | 1,296.60 ± 51.96 | 884.69 ± 27.03 | 118.74 ± 4.11 |
| AUC0-∞ | min μg/ml | 141.59 ± 8.36 | 1,314.58 ± 48.45 | 902.94 ± 28.41 | 132.18 ± 6.89 |
| T1/2 | Min | 67.30 ± 4.13 | 30.39 ± 1.17 | 32.99 ± 1.02 | 60.52 ± 6.15 |
| MRT | Min | 234.35 ± 9.60 | 182.01 ± 1.44 | 215.90 ± 2.18 | 214.54 ± 14.69 |
| AUCbrain/A | — | 11.04 ± 0.50 | 59.07 ± 2.78 | 21.69 ± 0.99 | 2.69 ± 0.34 |
| AUCblood/% | |||||