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. 2020 Apr 30;14:95. doi: 10.3389/fncel.2020.00095

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Copyright © 2020 Buckley, O’Brien, Brosnan, Ross, Stanton, Buckley and O’Malley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exendin-4 enhances colonic secretory currents. (A) The representative secretory traces from Ussing chamber studies and the associated scatter plots illustrate the secretory current evoked by the GLP-1R agonist, exendin 4 (Ex-4, 10 μM, n = 8). (B) Ex-4 does not modify the cholinergically-mediated secretory current (I_SC) evoked by carbachol (10 μM, n = 8) but enhances currents evoked by the (C) sodium channel agonist, veratridine (10 μM, n = 8) and (D) the sensory nerve stimulant, capsaicin (1 μM, n = 8). (E) Ex-4 also increases transepithelial resistance (TER) throughout an experiment (60–90 min). *p < 0.05, **p < 0.01.