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(A, B) mGluR5−/− mice exhibit despair-like behaviors after stress exposure. (A) Anxiety-like behaviors assessed in OF tests. (B) Anxiety-like behaviors assessed in EPM tests. (C) The immobility in FST was measured during the last 4 min of the 6-min video. Two-sided t-test, *P < 0.05. (D) The immobility time of TST was measured during the last 4 min of the 6-min video. Two-sided t-test, *P < 0.05. n = 7 mice for mGluR5+/+ and 7 for mGluR5−/−.
