Table 2. Association Results for Index Markers.
| SNV | Locus | Risk allele | Discovery | Replication | Meta-analysis | Candidate genes | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RAF in cases/controls | OR (95% CI) | P value | q Value | RAF cases/controls | OR (95% CI) | P value | OR (95% CI) | P value | ||||
| rs4970935 (I) | 1q21.3 | C | 0.37/0.25 | 1.78 (1.51-2.09) | 2.63 × 10−12 | 3.63 × 10−7 | 0.40/0.26 | 1.74 (1.34-2.26) | 3.37 × 10−5 | 1.77 (1.54-2.03) | 3.26 × 10−16 | ECM1,a,c C1orf54,b,d ADAMTSL4,a,c and MRPS21b,c |
| rs9349379 (G) | 6p24.1 | A | 0.73/0.59 | 1.77 (1.51-2.09) | 7.09 × 10−12 | 8.73 × 10−7 | 0.70/0.60 | 1.57 (1.20-2.06) | 9.90 × 10−4 | 1.71 (1.49-1.97) | 4.59 × 10−14 | PHACTR1a,c,d |
| rs11172113 (G) | 12q13.3 | T | 0.71/0.59 | 1.67 (1.42-1.97) | 3.62 × 10−10 | 3.26 × 10−5 | 0.71/0.58 | 1.75 (1.33-2.31) | 6.82 × 10−5 | 1.69 (1.47-1.94) | 1.42 × 10−13 | LRP1a,c,d |
| rs67049921 (I) | 16q24.1 | G | 0.90/0.83 | 1.91 (1.49-2.44) | 2.56 × 10−7 | 5.21 × 10−3 | 0.84/0.84 | 0.96 (0.69-1.35) | 0.83 | 1.51 (1.23-1.84) | 5.40 × 10−5 | NA |
| rs6700122 (I) | 1q24.2 | T | 0.11/0.06 | 2.10 (1.58-2.79) | 2.88 × 10−7 | 5.43 × 10−3 | 0.11/0.09 | 1.25 (0.83-1.88) | 0.28 | 1.77 (1.41-2.24) | 1.40 × 10−6 | NA |
| rs28451064 (I) | 21q22.11 | G | 0.93/0.86 | 2.11 (1.59-2.82) | 3.12 × 10−7 | 5.75 × 10−3 | 0.95/0.88 | 2.44 (1.45-4.09) | 7.61 × 10−4 | 2.18 (1.70-2.81) | 1.09 × 10−9 | LINC00310a,d |
| rs189056 (I) | 3q22.3 | A | 0.45/0.36 | 1.47 (1.26-1.71) | 6.65 × 10−7 | 8.98 × 10−3 | 0.43/0.41 | 1.06 (0.82-1.37) | 0.65 | 1.35 (1.18-1.54) | 7.53 × 10−6 | NA |
| rs2015637 (I) | 15q21.1 | C | 0.16/0.10 | 1.75 (1.40-2.18) | 7.23 × 10−7 | 9.71 × 10−3 | 0.18/0.10 | 1.91 (1.31-2.78) | 7.02 × 10−4 | 1.79 (1.48-2.17) | 2.12 × 10−9 | FBN1a,d |
| rs10095937 (I) | 8q24.3 | G | 0.06/0.02 | 2.57 (1.76-3.75) | 9.65 × 10−7 | 0.01 | 0.04/0.04 | 0.87 (0.46-1.68) | 0.69 | 1.96 (1.41-2.71) | 5.74 × 10−5 | NA |
| rs79603310 (I) | 4q34.3 | C | 0.14/0.08 | 1.84 (1.44-2.35) | 9.8 × 10−7 | 0.01 | 0.12/0.13 | 0.94 (0.64-1.38) | 0.74 | 1.52 (1.24-1.87) | 7.32 × 10−5 | NA |
Abbreviations: G, genotyped; I, imputed; OR, odds ratio; RAF, risk allele frequency; SNV, single-nucleotide variation.
a
Gene nearest to the index SNV.
b
Gene overlapping SNV within strong linkage disequilibrium (r2>0.8) of index SNV.
c
Expression quantitative trait locus target gene for the index SNV.
d
Gene ranked in the top 5 for coronary artery, aorta, or tibial artery expression.