FIGURE 3.

Immune-mediated pathology is induced upon prolonged treatment with MLT-943. (A) Eosinophil and (B) Basophil counts in peripheral blood, analyzed on day 34 (week 5), day 86 (week 13) or at time point of early euthanasia as indicated. (C) Progression of histological alterations in Wistar rats treated with MLT-943 for up to 13 weeks. All animals were males and belonged to the 80 mg/kg/day groups if not stated otherwise in the picture. Sections were taken at necropsy day 27 (week 4) or day 86 (week 13; except for cecum 13 week MLT-943, early death day 80) and stained with H&E. Mononuclear cell infiltration in salivary glands, pancreas and stomach (*). Mixed cell infiltration (white arrow), globule leukocytes (black arrow) in stomach/cecum (higher resolution pictures in Supplementary Figure S3A).