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. 2020 Apr 30;11:745. doi: 10.3389/fimmu.2020.00745

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Copyright © 2020 Martin, Junker, Tritto, Sutter, Rubic-Schneider, Morgan, Niwa, Li, Schlapbach, Walker, Bigaud, Beerli, Littlewood-Evans, Rudolph, Laisney, Ledieu, Beltz, Quancard, Bornancin, Zamurovic Ribrioux and Calzascia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Thymectomy does not prevent the MLT-943-associated Treg reduction and immunopathology. (A) Outline of the 9-week thymectomy study including surgery, regeneration time after surgery (2 weeks) and 9 weeks MLT-943 or vehicle dosing phase. (B–E) Tissues and peripheral blood from male and female rats were harvested at necropsy (day 63) and analyzed by standard hematology (cell counts) or FACS. (B) Cell counts in spleen and LN in the indicated groups. (C) Frequency of Foxp3⁺ Tregs in blood in the indicated groups. (D) Frequency of indicated T cell subpopulations in blood. (E) Percentage of IFNγ-producing, IL-4-negative CD4 and CD8 T cells isolated from blood, detected by intracellular FACS staining after 4 h PMA/Ionomycin stimulation ex vivo. Graphs depict means ± SEM. (F) Serum IgE levels in male and female rats at day 35 (week 5) and day 63 (week 9) of MLT-943 or vehicle treatment.