TABLE 2.

Partial recovery of histological findings in selected tissues after 13 weeks treatment with MLT-943 followed by an 8-week recovery period – incidence and mean severity of affected animals.

Treatment/finding	0 mg/kg after 13 weeks		0 mg/kg after recovery		MLT-943 80 mg/kg after 13 weeks		MLT-943 80 mg/kg after recovery
Sex	Male	Female	Male	Female	MALE	Female	Male	Female
No. animals/group	10	10	6	6	11*	14*	5	2
Degeneration/regeneration, stomach	0 (−)	0 (−)	0 (−)	0 (−)	4 (1.3)	2 (1.5)	0 (−)	0 (−)
Mononuclear cell infiltration, stomach	0 (−)	0 (−)	0 (−)	1 (2.0)	8 (1.8)	8 (1.4)	3 (1.3)	0 (−)
Globule leukocytes, stomach	4 (1.0)	3 (1.0)	2 (1.0)	3 (1.0)	11 (2.1)	12 (2.0)	3 (1.0)	1 (3.0)
Degeneration/regeneration, cecum	0 (−)	0 (−)	0 (−)	0 (−)	6 (2.7)	6 (2.0)	0 (−)	0 (−)
Mixed cell infiltration, cecum	0 (−)	0 (−)	0 (−)	0 (−)	10 (2.1)	9 (2.1)	1 (1.0)	1 (1.0)
Globule leukocytes, cecum	0 (−)	0 (−)	0 (−)	0 (−)	10 (2.5)	9 (2.7)	0 (−)	0 (−)
Mononuclear cell infiltration, parotid salivary gland	0 (−)	0 (−)	1 (1.0)	1 (1.0)	5 (1.6)	4 (1.0)	3 (1.0)	1 (1.0)
Mononuclear cell infiltration, pancreas	2 (1.0)	0 (−)	2 (1.0)	0 (−)	5 (1.4)	7 (1.6)	4 (1.0)	2 (1.0)

Severity grading: 1, minimal; 2, mild; 3, moderate; 4, marked; (), mean severity of affected animals/group * including early sacrifices/deaths.