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. Author manuscript; available in PMC: 2020 May 7.
Published in final edited form as: J Org Chem. 2019 Oct 9;84(21):13232–13241. doi: 10.1021/acs.joc.9b00537

Figure 2.

Figure 2.

The total antibody (A), IgG antibody (B) and IgM antibody (C) titers of pooled day 21 and 43 sera from mice immunized with conjugates 16a and 16b. ELISA plates were coated with 17a and 17b to detect antibodies specific to the carbohydrate antigen in 16a and 16b, respectively. Antibody titers were calculated according to the method described in the experimental section. The mean value of three parallel experiments was shown for each sample, and the error bar showed the standard error of mean (SEM). *p < 0.05, **p < 0.01 and ***p < 0.001 as compared to normal serum; #p < 0.05 between the two groups.