Table 3.
Univariate and multivariate analysis, contrasting the risk of relapse of PTC patients with clinical, pathological and molecular features.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (CI95%) | P | HR (CI95%) | P | |
| Age | ||||
| <55 years | 1.0 | |||
| ≥55 years | 0.6 (0.2–2.1) | 0.476 | ||
| Gender | ||||
| Female | 1.0 | 1.0 | ||
| Male | 2.3 (1.1–4.6) | 0.020 | 1.6 (0.7–3.4) | 0.241 |
| Tumor Dimension | ||||
| ≤1 cm | 1.0 | |||
| >1 cm | 2.0 (1.0–5.0) | 0.062 | ||
| Multicentricity | ||||
| No | 1.0 | |||
| Yes | 2.0 (1.0–4.0) | 0.062 | ||
| Histological Variant | ||||
| Classical | 1.0 | |||
| Other | 2.0 (0.8–5.2) | 0.148 | ||
| Vascular/Perineural Invasion | ||||
| No | 1.0 | 1.0 | ||
| Yes | 3.2 (1.4–7.4) | 0.007 | 1.8 (0.6–4.9) | 0.271 |
| Extrathyroidal Extension | ||||
| No | 1.0 | |||
| Yes | 1.8 (0.9–3.7) | 0.091 | ||
| Lymph Node Metastasis | ||||
| No | 1.0 | 1.0 | ||
| Yes | 4.1 (2.0–8.4) | <0.001 | 3.0 (1.3–6.9) | 0.009 |
| BRAF Mutation | ||||
| No | 1.0 | |||
| Yes | 1.1 (0.5–2.2) | 0.867 | ||
| RAS Mutation | ||||
| No | 1.0 | |||
| Yes | 0 (0–848.7) | 0.542 | ||
| RET/PTC | ||||
| No | 1.0 | |||
| Yes | 1.0 (0.2–4.4) | 0.972 | ||
| TERT Promoter Mutation | ||||
| No | 1.0 | |||
| Yes | 1.4 (0.2–10.4) | 0.728 | ||
| GADD45B Expression | ||||
| Bellow median | 1.0 | 1.0 | ||
| Above median | 3.6 (1.5–8.4) | 0.003 | 2.9 (1.2–7.0) | 0.015 |
HR, Hazard ratio; CI, confidence interval. P-value, Cox proportional-hazards regression. The bold values are statistically significant.