Table 6.

Viral outcome categories for HBV treatment used in sensitivity analysis

Favourable viral outcomes:
Fully suppressed	HBV DNA undetectable for study period OR HBV DNA became undetectable with no further rise
Adequate viral suppression	Where treatment duration was < 2 years, HBV DNA decreased > 1 log10
Unfavourable viral outcomes:
Not suppressed	Detectable HBV DNA after 2 years on treatment
Non-transient rise	< 1 log rise in HBV DNA which was not a transient rise
Viral breakthrough	≥1x log10 rise in HBV DNA level from nadir which was not a transient rise
Transient rise	a single instance of increased DNA level < 150 IU/ML with return to undetectable at next test