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. 2020 May 7;25:30. doi: 10.1186/s11658-020-00222-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The interaction between miR-637 and IGF-2. a – TargetScan database prediction of the binding sites between IGF-2 and miR-637. b – The targeted relationship between miR-637 and IGF-2 was verified using a dual luciferase reporter gene assay. c and d – The expressions of miR-637 and IGF-2 mRNA showed different trends depending on the ox-LDL concentrations and treatment time. e – The expression of IGF-2 mRNA was determined using real-time PCR after treatment with miR-637 mimics, 100 mg/l ox-LDL or miR-637 mimics+ 100 mg/l ox-LDL. f – The expression of IGF-2 mRNA was determined using real-time PCR after treatment with miR-637 inhibitors, 100 mg/l ox-LDL or miR-637 inhibitors+ 100 mg/l ox-LDL. g – The expression of IGF-2 was determined using western blotting after treatment with miR-637 mimics, 100 mg/l ox-LDL or miR-637 mimics+ 100 mg/l ox-LDL. h – The expression level of IGF-2 was determined using western blotting after treatment with miR-637 inhibitors, 100 mg/l ox-LDL or miR-637 inhibitors+ 100 mg/l ox-LDL. *, ** and *** respectively indicate p < 0.05, p < 0.01 and p < 0.001