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. 2020 May 6;22:42. doi: 10.1186/s13058-020-01282-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The extracted numerical collagen structural parameters are relevant with DCIS association. a ATC and DTC CAR are significantly higher in patients with positive DCIS association compared with those with no DCIS association. b ATC and DTC CFD are increased in patient samples with positive DCIS association. The CAR and CFD results indicate that the collagen may form a stronger protective barrier surrounding the tumor nests. c DTC CFL significantly increases for patients with DCIS associations. d ATC CFT and DTC CFT significantly differed between patients with DICS associations and those with no DCIS associations. Error bars represent SE of the mean. *p < 0.05, **p < 0.0, ***p < 0.001, and ^>***p < 0.0001, with comparisons indicated by lines. p values calculated using one-way ANOVA and Tukey’s HSD test