Figure 2.

Abnormal locomotive and cognitive flexibility in MECP2 monkeys. A, Peer separation paradigm. The test monkey was able to have visual, auditory, and olfactory interactions with the peer monkey during the interaction stage. B, Excessive locomotion during home cage observation in TG monkeys in terms of general locomotion time (left) and repetitive index (right). C, Larger induced locomotion change in TG monkeys after peer separation. ***p < 0.0001, **p < 0.001, *p < 0.05. D, Temporal sequence of events in the color discrimination and reversal learning task. RT, Reaction time; MT, movement time; ITI, intertrial interval. E, An example of task sequence in the reversal learning test. The color assigned for reward was pseudorandomly switched between sessions. G, Green-reward session; B, blue-reward session. F, The cumulative regressive error rate of performed trials after rule switch was analyzed (n = 5, TG; n = 4, WT; *p < 0.05, two-sample Student's t test). Error bars denote SEM. G, The percentage of regressive errors in TG and WT groups in the first 20 performed trials after rule switch (Student's t test).