Figure 1.

Striatal A₁R and A_2AR protein expression following three or eight weeks of wheel running. Representative immunohistochemistry images for A₁R in the mouse striatum following eight weeks of (a) sedentary conditions and (b) running wheel access. (c) Relative levels of A₁R protein density represented as averages across sections as detailed in the Methods. Representative immunohistochemistry images for A_2AR in the mouse striatum following eight weeks of (d) sedentary conditions and (e) running wheel access. (f) Relative levels of A_2AR protein density represented as averages across sections as detailed in Methods. Statistical significance denoted as follows: sedentary 8 weeks vs. runner 8 weeks at ^Ap < 0.05, ^Bp < 0.01, and ^Cp < 0.001. Sedentary 8 weeks vs. runner 3 weeks at ^Dp < 0.05, ^Ep < 0.01, and ^Fp < 0.001. Sedentary 8 weeks vs. sedentary 3 weeks at ^Gp < 0.05, ^Hp < 0.01, and ^Ip < 0.001. Runner 8 weeks vs. sedentary 3 weeks at ^Jp < 0.05. Runner 8 weeks vs. runner 3 weeks at ^Kp < 0.05 and ^Lp < 0.01. Sedentary 3 weeks vs. runner 3 weeks at ^Mp < 0.05.