Table 2.
Pathways that overlapped between expression profiling data from two studies of colon biopsies of pediatric ulcerative colitis (z‐score > 2 and P value < 0.05).
| Positive canonical pathway | Activation z-score | P value | ||
|---|---|---|---|---|
| GSE9686 | GSE10616 | GSE9686 | GSE10616 | |
| Th1 pathway | 4.160 | 4.012 | 6.76E-04 | 1.20E-04 |
| GP6 signaling pathway∗ | 3.969 | 3.429 | 1.78E-03 | 4.90E-03 |
| Tec kinase signaling | 3.810 | 2.714 | 2.34E-03 | 1.29E-02 |
| IL-8 signaling∗ | 3.666 | 3.349 | 6.17E-03 | 1.17E-02 |
| Colorectal cancer metastasis signaling | 3.334 | 2.333 | 1.66E-03 | 5.13E-04 |
| TREM1 signaling | 3.317 | 3.651 | 3.02E-05 | 3.24E-03 |
| Role of pattern recognition receptors in recognition of bacteria and viruses∗ | 3.280 | 2.746 | 2.29E-02 | 1.29E-02 |
| Systemic lupus erythematosus in the T cell signaling pathway | 3.200 | 3.118 | 3.98E-03 | 2.69E-03 |
| Production of nitric oxide and reactive oxygen species in macrophages∗ | 3.130 | 3.048 | 1.23E-02 | 3.02E-03 |
| PKCθ signaling in T lymphocytes∗ | 3.046 | 2.771 | 8.13E-03 | 9.33E-04 |
| Leukocyte extravasation signaling | 2.951 | 2.630 | 3.72E-07 | 1.82E-07 |
| Acute phase response signaling | 2.898 | 2.263 | 6.92E-03 | 1.38E-03 |
| Neuroinflammation signaling pathway∗ | 2.866 | 2.360 | 9.12E-03 | 1.15E-03 |
| Osteoarthritis pathway∗ | 2.862 | 3.022 | 9.33E-04 | 1.82E-05 |
| CD28 signaling in T helper cells | 2.654 | 2.271 | 4.57E-02 | 2.24E-03 |
| LPS/IL-1-mediated inhibition of RXR function | 2.592 | 2.466 | 1.45E-05 | 1.23E-06 |
| Chondroitin and dermatan biosynthesis∗ | 2.236 | 2.236 | 3.39E-02 | 6.76E-03 |
∗ indicates a pathway that has not been described in pediatric UC. GP6: glycoprotein VI; IL-8: interleukin-8; TREM1: triggering receptor expressed on myeloid cell-1; PKCθ: protein kinase C theta; LPS: lipopolysaccharides; IL-1: interleukin-1; RXR: retinoid X receptor.