Table 3.
List of differentially expressed predicted upstream regulators (excluding receptors).
| Gene symbol | Log FC | Activation z-score | ||
|---|---|---|---|---|
| GSE9686 | GSE10616 | GSE9686 | GSE10616 | |
| IL1B | 2.471 | 2.167 | 8.740 | 8.695 |
| IL1A | 2.144 | 1.794 | 6.531 | 6.501 |
| IFNG | 1.882 | 1.499 | 6.401 | 7.570 |
| TGFB1 | 1.106 | 0.821 | 5.649 | 5.841 |
| IL17A | 0.527 | 0.411 | 5.390 | 5.877 |
| IL6 | 2.407 | 1.970 | 5.218 | 5.250 |
| F3 | 1.659 | 1.392 | 4.167 | 4.082 |
| EDN1 | -1.789 | -1.526 | 4.120 | 4.969 |
| CXCL12 | 1.624 | 0.916 | 4.042 | 4.590 |
| TGFB3 | 1.375 | 0.943 | 3.806 | 3.694 |
| TYROBP | 1.941 | 1.479 | 3.582 | 3.138 |
| SELP | 1.499 | 1.462 | 3.484 | 3.194 |
| CSF1 | -0.484 | -0.289 | 3.431 | 3.514 |
| TREM1 | 1.325 | 1.291 | 3.356 | 3.195 |
| FGF2 | 0.662 | 0.480 | 3.263 | 3.827 |
| NAMPT | 1.331 | 1.048 | 3.115 | 3.115 |
| CCL11 | 3.210 | 2.610 | 3.068 | 3.164 |
| WNT5A | 3.419 | 2.573 | 3.031 | 2.883 |
| IL36B | -0.370 | -0.301 | 2.957 | 2.803 |
| PF4 | 1.140 | 1.217 | 2.950 | 3.270 |
| TNFSF13B | 2.349 | 1.714 | 2.758 | 2.661 |
| TNFSF11 | 2.151 | 1.625 | 2.654 | 3.091 |
| IFNW1 | -0.585 | -0.458 | 2.639 | 2.442 |
| HGF | 0.758 | 0.748 | 2.619 | 3.894 |
| TNFSF15 | 1.055 | 0.782 | 2.568 | 2.568 |
| IL33 | 2.022 | 1.671 | 2.562 | 2.300 |
| ITGAM | 1.752 | 1.296 | 2.414 | 2.200 |
| CXCL8 | 3.365 | 3.204 | 2.393 | 2.781 |
| CCL2 | 3.748 | 2.672 | 2.376 | 2.471 |
| GDNF | -0.312 | -0.340 | 2.357 | 2.327 |
| IL3 | -0.570 | -0.340 | 2.320 | 2.174 |
| AGT | 3.578 | 2.725 | 2.219 | 2.979 |
IL1B: interleukin 1B; IFNG: interferon gamma; IL1A: interleukin 1A; TGFB1: transforming growth factor beta 1; IL17A: interleukin 17A; IL6: interleukin 6; EDN1: endothelin 1; CXCL12: C-X-C motif chemokine ligand 12; TGFB3: transforming growth factor beta 3; FGF2: fibroblast growth factor 2; CSF1: colony-stimulating factor 1; TYROBP: TYRO protein tyrosine kinase binding protein; SELP: selectin P; TREM1: triggering receptor expressed on myeloid cell-1; HGF: hepatocyte growth factor; CCL11: C-C motif chemokine 11; NAMPT: nicotinamide phosphoribosyltransferase; PF4: platelet factor 4; WNT5A: Wnt family member 5A; IL36B: interleukin 36B; TNFSF11: TNF superfamily member 11; TNFSF13B: TNF superfamily member 13b; AGT: angiotensinogen; CXCL8: C-X-C motif chemokine ligand 8; TNFSF15: TNF superfamily member 15; IFNW1: interferon omega 1; IL33: interleukin 33; CCL2: C-C motif chemokine ligand 2; GDNF: glial cell-derived neurotrophic factor; ITGAM: integrin subunit alpha M; IL3: interleukin 3.