Table 3.
Optimal cutoff values for biomarkers in predicting CIN.
| Cutoff point | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|
| sNGAL_p (ng/ml) | 63.15 | 0.84 | 0.45 | 0.50 | 0.81 |
| sNGAL_24 (ng/ml) | 80.81 | 0.74 | 0.52 | 0.47 | 0.78 |
| sNGAL_48 (ng/ml) | 72.95 | 0.70 | 0.62 | 0.50 | 0.79 |
| sCystatin C_p (ng/ml) | 893.43 | 0.37 | 0.96 | 0.88 | 0.70 |
| sCystatin C_24 (ng/ml) | 856.59 | 0.52 | 0.90 | 0.75 | 0.77 |
| sCystatin C_48 (ng/ml) | 764.32 | 0.52 | 0.86 | 0.67 | 0.78 |
| Sβ2M_p (μg/ml) | 3.6 | 0.88 | 0.45 | 0.48 | 0.87 |
| Sβ2M_24 (μg/ml) | 4.3 | 0.71 | 0.61 | 0.51 | 0.78 |
| Sβ2M_48 (μg/ml) | 5.1 | 0.57 | 0.88 | 0.72 | 0.80 |
| IL18_p (pg/ml) | 182.0 | 0.48 | 0.80 | 0.60 | 0.71 |
| IL18_24 (pg/ml) | 161.2 | 0.50 | 0.67 | 0.48 | 0.68 |
| IL18_48 (pg/ml) | 116.6 | 0.75 | 0.60 | 0.50 | 0.81 |
sNGAL and uNGAL, serum and urine neutrophil gelatinase-associated lipocalin; sIL18 and uIL18, serum and urine interleukin 18; sβ2M, serum beta 2 microglobulin.