Table 5.

Effect of SB202190 on the mRNA expression of proinflammatory cytokines in IPEC-1 cells stimulated with H₂O₂.

Items1	-H2O2		+H2O2		P value
	Control	SB202190	Control	SB202190	SB202190	H2O2	Interactions
IL-6	1.00 ± 0.05b	0.29 ± 0.01a	5.33 ± 0.28d	2.31 ± 0.14c	<0.001	<0.001	<0.001
IL-8	1.00 ± 0.09	0.54 ± 0.01	4.61 ± 0.58	3.04 ± 0.22	0.012	<0.001	0.112
TNF-α	1.00 ± 0.10a	0.86 ± 0.14a	6.09 ± 0.35c	2.84 ± 0.21b	<0.001	<0.001	<0.001

^a-dMeans within a row with different letters differ significantly (P ≤ 0.05). ¹The 2^−ΔΔCt method was used to analyze the relative mRNA expression (fold changes), calculated relative to the values in the control group.