Table 2.

Pharmacokinetic parameters estimated from literature

		ka	ke	Dc	τc	VdS−1F−1a
Imatinib	[49]	20	0.86	810	1	0.24
Nilotinib	[50]	30	1.5	760	0.5	0.31
Dasatinib	[51]	21	5.2	200	1	1.3
Bosutinib	[52]	10	0.71	750	1	2.5
Ponatinib	[53]	11	0.76	84	1	0.50
Axitinib	[54]	23	4.1	13 b	1	0.15
Asciminib	[55]	27	1.6	88 b	1	0.076

^aCalculated as one variable during parametrization

^bEstimates of a tolerable dose. No standard doses have been established as these are not conventional treatments

^cFrom standard treatment [56]