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. 2020 May 6;20:152. doi: 10.1186/s12935-020-01223-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — FENDRR regulates CC by modulating miR-15a/b-5p/TUBA1A axis. a Bioinformatics analysis of possible mRNAs sharing binding sites with miR-15a/b-5p. b The expression of selected mRNA by qRT-PCR. c Relevant gene expression after overexpressing FENDRR. d TUBA1A relative expression in CC cells. e Overexpression efficiency test. f, h TUBA1A gain-of-function experiments by CCK-8, colony formation assay and transwell assays. i Coexistence verification of indicated molecules. j Pull down assay detected the PCR product of miR-15a/b-5p. k The interaction among FENDRR, miR-15a/b-5p and TUBA1A was demonstrated by luciferase reporter assay. The putative binding sites from StarBase were also verified. **p < 0.01; n.s. not significant