Table 2.
Performance evaluation of PheLEx in improving GWAS discovery
| Misclassification | Median AUC ROCa | Median AUC PRb | ||
|---|---|---|---|---|
| Simulated Misclassified phenotype | PheLEx corrected phenotype | Simulated Misclassified phenotype | PheLEx corrected phenotype | |
| 0% (no misclassification) | 0.701 | 0.697 | 0.0769 | 0.0739 |
| 1% | 0.696 | 0.696 | 0.0710 | 0.0720 |
| 3% | 0.686 | 0.688 | 0.0625 | 0.0651 |
| 5% | 0.680 | 0.681 | 0.0527 | 0.0553 |
| 8% | 0.669 | 0.669 | 0.0428 | 0.0458 |
| 10% | 0.661 | 0.663 | 0.0359 | 0.0403 |
aAUC ROC = Area under Receiver Operating Characteristic curve
bAUC PR = Area under Precision Recall curve