Table 3.

PheLEx discoveries identified for UK Biobank bipolar disorder phenotype

UK Biobank phenotype	SNP	Locus	p-valuea in original phenotype	p-valuea in corrected phenotype	r2b	Genesc	MAFd
Bipolar Disorder	rs112071029	11:132129335	1.23e−5	6.74e−7	4e− 4	NTM, OPCML, NTM-IT, C11orf39	0.0423
	rs17028986	3:11913699	1.13e−5	1.58e− 6	3.8e−4	TAMM41, SYN2, PPARG, TIMP4, ATG7, VGLL4	0.0925
Epilepsy	rs114011598	3:11913699	2.90e−5	1.55e−6	1e−4	ZLPD1, LOC152225, NXPE3, NFKBIZ	0.036

^a unadjusted p-values

^b Maximum r² with training SNPs

^c Genes with loci in linkage disequilibrium with loci where all annotations were performed using web-resource LDLink

^d MAF = Minor Allele Frequency