Table 3.
Results of pooled analysis of each polymorphism based on five genetic models
| Polymorphism, (number of studies) | G vs. A | GG vs. AA | AG vs. AA | AG + GG vs. AA | GG vs. AA + AG |
|---|---|---|---|---|---|
| OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | |
| LTF rs1126478 (n = 4) | 0.98 (0.87, 1.10), 0.68, 25, 0.26 | 1.03 (0.80, 1.33), 0.82, 4, 0.37 | 1.00 (0.80, 1.25), 0.99, 4, 0.44 | 0.99 (0.81, 1.23), 0.96, 7, 0.36 | 0.95 (0.80, 1.13), 0.58, 0, 0.45 |
| ENAM rs1264848 (n = 5) | 0.93 (0.65, 1.32), 0.68, 75, 0.003 | 0.88 (0.34, 2.30), 0.79, 76, 0.002 | 1.21 (0.88, 1.65), 0.24, 0, 0.48 | 1.24 (0.93, 1.67), 0.15, 24, 0.26 | 0.83 (0.44, 1.58), 0.58, 79, 0.0007 |
| ENAM rs3796704 (n = 4) | 1.38 (1.08, 1.76), 0.009, 27, 0.25 | 1.86 (0.96, 3.62), 0.07, 44, 0.17 | 1.27 (0.64, 2.52), 0.49, 50, 0.13 | 1.64 (0.86, 3.14), 0.13, 43, 0.17 | 1.41 (1.06, 1.87), 0.02, 18, 0.30 |
| Polymorphism, (number of studies) | T vs. C | TT vs. CC | CT vs. CC | CT + TT vs. CC | TT vs. CC + CT |
| OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | |
| ENAM rs3796703 (n = 2) | 0.92 (0.24, 3.58), 0.91, 78, 0.03 | 5.22 (0.25, 108.96), 0.29 | 0.89 (0.23, 3.48), 0.87, 77, 0.04 | 0.90 (0.23, 3.63), 0.89, 78, 0.03 | 2.90 (0.92, 9.12), 0.07, 0, 0.69 |
| AMELX rs946252 (n = 3) | 1.01 (0.68, 1.51), 0.95, 39, 0.20 | 1.27 (0.58, 2.75), 0.55, 0, 0.51 | 1.45 (0.75, 2.81), 0.27, 31, 0.23 | 1.21 (0.68, 2.14), 0.52, 0, 0.51 | 0.82 (0.43, 1.56), 0.54, 0.38, 0.20 |
| AMELX rs17878486 (n = 4) | 2.25 (0.81, 6.24), 0.12, 86, 0.0001 | 3.59 (0.55, 23.32), 0.18, 81, 0.001 | 1.45 (0.36, 5.80), 0.60, 0.67, 0.03 | 2.30 (0.51, 10.33), 0.28, 77, 0.004 | 3.10 (0.85, 11.28), 0.09, 81, 0.001 |
| AMELX rs6639060 (n = 2) | 1.08 (0.63, 1.85), 0.78 | 1.04 (0.43, 2.51), 0.94 | 1.27 (0.49, 3.30), 0.63 | 1.14 (0.56, 2.29), 0.72 | 1.00 (0.42, 2.39), 1.00 |
| AMELX rs2106416 (n = 3) | 0.59 (0.16, 2.11), 0.41, 82, 0.003 | 1.83 (0.47, 7.06), 0.38, 40, 0.20 | 0.55 (0.13, 2.25), 0.40, 80, 0.006 | 0.59 (0.15, 2.31), 0.45, 79, 0.008 | 1.67 (0.44, 6.34), 0.45, 31, 0.23 |
Abbreviations: LTF Lactotransferrin, ENAM Enamelin, AMELX Amelogenin X, NA Not available, OR Odds ratio, CI Confidence interval; Ph, Pheterogeneity