Table 4.
Subgroup analysis of each polymorphism based on ethnicity, age group, and control group
| Polymorphism, (number of studies) | G vs. A | GG vs. AA | AG vs. AA | AG + GG vs. AA | GG vs. AA + AG |
|---|---|---|---|---|---|
| OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | |
| LTF rs1126478 | |||||
| Ethnicity | |||||
| Caucasian (2) | 1.18 (0.66, 2.11), 0.58, 73, 0.05 | 1.49 (0.58, 3.85), 0.41, 55, 0.13 | 1.02 (0.53, 1.97), 0.95, 53, 0.14 | 1.16 (0.53, 1.97), 0.95, 0.53, 0.14 | 1.33 (0.77, 2.29), 0.30, 6, 0.30 |
| Asian (2) | 0.96 (0.84, 1.09), 0.52, 0, 0.98 | 0.97 (0.73, 1.29), 0.81, 0, 0.99 | 1.07 (0.80, 1.43), 0.64, 0, 0.96 | 1.02 (0.78, 1.33), 0.91, 0, 0.97 | 0.92 (0.77, 1.10), 0.35, 0, 0.96 |
| Age group | |||||
| Children (4) | 0.98 (0.87, 1.10), 0.68, 25, 0.26 | 1.03 (0.80, 1.33), 0.82, 4, 0.37 | 1.00 (0.80, 1.25), 0.99, 4, 0.44 | 0.99 (0.81, 1.23), 0.96, 7, 0.36 | 0.95 (0.80, 1.13), 0.58, 0, 0.45 |
| Control group | |||||
| Caries free (4) | 0.98 (0.87, 1.10), 0.68, 25, 0.26 | 1.03 (0.80, 1.33), 0.82, 4, 0.37 | 1.00 (0.80, 1.25), 0.99, 4, 0.44 | 0.99 (0.81, 1.23), 0.96, 7, 0.36 | 0.95 (0.80, 1.13), 0.58, 0, 0.45 |
| ENAM rs1264848 | |||||
| Ethnicity | |||||
| Caucasian (4) | 0.86 (0.56, 1.32), 0.49, 80, 0.002 | 0.67 (0.18, 2.45), 0.54, 82, 0.0009 | 1.13 (0.80, 1.59), 0.48, 0, 0.45 | 1.18 (0.86, 1.62), 0.31, 35, 0.20 | 0.76 (0.34, 1.72), 0.51, 84, 0.0003 |
| Mixed (1) | 1.23 (0.79,1.91), 0.36 | 1.62 (0.64, 4.09), 0.31 | 1.73 (0.77, 3.90), 0.18 | 1.69 (0.78, 3.68), 0.18 | 1.09 (0.53, 2.23), 0.82 |
| Age group | |||||
| Children (4) | 0.82 (0.57, 1.18), 0.28, 67, 0.03 | 0.58 (0.19, 1.82), 0.35, 74, 0.01 | 1.30 (0.84, 2.01), 0.26, 3, 0.36 | 1.16 (0.76, 1.75), 0.49, 42, 0.16 | 0.66 (0.37, 1.17), 0.15, 70, 0.02 |
| Control group | |||||
| Caries free (3) | 0.79 (0.39, 1.63), 0.53, 86, 0.0006 | 0.42 (0.03, 5.41), 0.51, 88, 0.0003 | 1.00 (0.66, 1.51), 1.00, 0, 0.44 | 0.74 (0.27, 2.02), 0.56, 55, 0.11 | 0.66 (0.15, 2.95), 0.59, 89, < 0.0001 |
| Low caries (2) | 1.03 (0.83, 1.29), 0.78, 0, 0.37 | 1.30 (0.79, 2.14), 0.30, 0, 0.59 | 1.57 (0.97, 2.53), 0.07, 0, 0.76 | 1.45 (0.92, 2.28), 0.11, 0, 0.62 | 0.90 (0.66, 1.23), 0.51, 0, 0.57 |
| ENAM rs3796704 | |||||
| Ethnicity | |||||
| Caucasian (3) | 1.43 (1.10, 1.85), 0.007, 45, 0.16 | 2.49 (1.19, 5.24), 0.02, 0, 0.85 | 1.74 (0.81, 3.74), 0.16, 0, 0.98 | 2.16 (1.05, 4.45), 0.04, 0, 0.85 | 1.41 (1.04, 1.91), 0.03, 45, 0.16 |
| Mixed (1) | 1.11 (0.57, 2.15), 0.77 | 0.27 (0.03, 2.47), 0.24 | 0.14 (0.01, 1.46), 0.10 | 0.24 (0.03, 2.17), 0.20 | 1.43 (0.67, 3.05), 0.36 |
| Age group | |||||
| Children (2) | 1.46 (0.92, 2.32), 0.11, 22, 0.26 | 0.61 (0.13, 2.93), 0.54, 38, 0.20 | 0.35 (0.07, 1.74), 0.20, 35, 0.22 | 0.54 (0.11, 2.56), 0.44, 37, 0.21 | 1.71 (1.02, 2.85), 0.04, 0, 0.53 |
| Control group | |||||
| Caries free (2) | 1.62 (1.21, 2.17), 0.001, 0, 0.59 | 2.499 (1.19, 5.24), 0.02, 0, 0.85 | 1.74 (0.81, 3.74), 0.16, 0, 0.98 | 2.16 (1.05, 4.45), 0.04, 0, 0.85 | 1.67 (1.17, 2.39), 0.0050, 0.58 |
| Low caries (2) | 0.97 (0.63, 1.50), 0.89, 0, 0.61 | 0.27 (0.03, 2.47), 0.24 | 0.14 (0.01, 1.46), 0.10 | 0.24 (0.03, 2.17), 0.20 | 1.05 (0.66, 1.68), 0.83, 0, 0.32 |
| Polymorphism, (number of studies) | T vs. C | TT vs. CC | CT vs. CC | CT + TT vs. CC | TT vs. CC + CT |
| OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | OR (95%CI), P-value, I2 (%), Ph | |
| ENAM rs3796703 | |||||
| Ethnicity | |||||
| Asian (2) | 0.92 (0.24, 3.58), 0.91, 78, 0.03 | 5.22 (0.25, 108.96), 0.29 | 0.89 (0.23, 3.48), 0.87, 77, 0.04 | 0.90 (0.23, 3.63), 0.89, 78, 0.03 | 2.90 (0.92, 9.12), 0.07, 0, 0.69 |
| Age group | |||||
| Children (2) | 0.92 (0.24, 3.58), 0.91, 78, 0.03 | 5.22 (0.25, 108.96), 0.29 | 0.89 (0.23, 3.48), 0.87, 77, 0.04 | 0.90 (0.23, 3.63), 0.89, 78, 0.03 | 2.90 (0.92, 9.12), 0.07, 0, 0.69 |
| AMELX rs946252 | |||||
| Ethnicity | |||||
| Caucasian (2) | 0.95 (0.35, 2.55), 0.92, 69, 0.07 | 1.42 (0.54, 3.76), 0.48, 17, 0.27 | 2.80 (0.93, 8.43), 0.07, 0, 0.38 | 1.63 (0.67, 4.01), 0.28, 0, 0.42 | 0.73 (0.19, 2.87), 0.66, 67, 0.08 |
| Mixed (1) | 0.99 (0.53, 1.86), 0.98 | 1.03 (0.28, 3.75), 0.96 | 0.95 (0.40, 2.25), 0.91 | 0.98 (0.46, 2.07), 0.95 | 1.04 (0.29, 3.75), 0.95 |
| Age group | |||||
| Children (2) | 1.21 (0.77,1.91), 0.42, 0, 0.37 | 1.54 (0.61, 3.92), 0.36, 0, 0.37 | 1.24 (0.61, 2.49), 0.56, 5, 0.31 | 1.24 (0.66, 2.33), 0.50, 24, 0.25 | 1.26 (0.56, 2.83), 0.25 |
| Control group | |||||
| Caries free (2) | 0.95 (0.35, 2.55), 0.92, 69, 0.07 | 1.42 (0.54, 3.76), 0.48, 17, 0.27 | 2.80 (0.93, 8.43), 0.07, 0, 0.38 | 1.63 (0.67, 4.01), 0.28, 0, 0.42 | 0.73 (0.19, 2.87), 0.66, 67, 0.08 |
| Low caries (1) | 0.99 (0.53, 1.86), 0.98 | 1.03 (0.28, 3.75), 0.96 | 0.95 (0.40, 2.25), 0.91 | 0.98 (0.46, 2.07), 0.95 | 1.04 (0.29, 3.75), 0.95 |
| AMELX rs17878486 | |||||
| Ethnicity | |||||
| Caucasian (2) | 2.87 (0.35, 23.23), 0.32, 95, < 0.0001 | 5.12 (0.09, 278.85), 0.42, 93, 0.0002 | 1.00 (0.12, 8.23), 1.00, 0.81, 0.02 | 2.03 (0.10, 42.44), 0.65, 92, 0.0004 | 6.17 (0.41, 92.05), 0.19, 91, 0.001 |
| Asian (1) | 1.38 (0.25, 7.75), 0.71 | 0.93 (0.04, 23.52), 0.97 | 0.33 (0.01, 12.82), 0.56 | 0.89 (0.04, 22.53), 0.95 | 1.89 (0.30, 11.85), 0.50 |
| Mixed (1) | 1.87 (1.06, 3.30), 0.03 | 3.82 (1.19, 12.21), 0.02 | 5.11 (1.33, 19.72), 0.02 | 4.03 (1.27, 12.75), 0.02 | 1.39 (0.69, 2.80), 0.35 |
| Age group | |||||
| Children (3) | 2.48 (0.76, 8.05), 0.13, 90, < 0.0001 | 4.69 (0.55, 40.16), 0.16, 86, 0.0007 | 1.72 (0.37, 7.92), 0.48, 75, 0.02 | 2.65 (0.49, 14.35), 0.26, 84, 0.002 | 3.55 (0.72, 17.60), 0.12, 87, 0.0004 |
| Adults (1) | 1.38 (0.25, 7.75), 0.71 | 0.93 (0.04, 23.52), 0.97 | 0.33 (0.01, 12.82), 0.56 | 0.89 (0.04, 22.53), 0.95 | 1.89 (0.30, 11.58), 0.50 |
| Control group | |||||
| Caries free (2) | 2.87 (0.35, 23.23), 0.32, 95, < 0.0001 | 5.12 (0.09, 278.85), 0.42, 93, 0.0002 | 1.00 (0.12, 8.23), 1.00, 0.81, 0.02 | 2.03 (0.10, 42.44), 0.65, 92, 0.0004 | 6.17 (0.41, 92.05), 0.19, 91, 0.001 |
| Low caries (2) | 1.82 (1.06, 3.11), 0.03, 0, 0.74 | 3.28 (1.14, 9.43), 0.03, 0, 0.42 | 3.42 (1.04, 11.28), 0.04, 47, 0.17 | 3.43 (1.21, 9.75), 0.02, 0, 0.39 | 1.44 (0.75, 2.77), 0.27, 0, 0.76 |
| AMELX rs6639060 | |||||
| Ethnicity | |||||
| Caucasian (1) | 1.08 (0.63, 1.85), 0.78 | 1.04 (0.43, 2.51), 0.94 | 1.27 (0.49,3.30), 0.63 | 1.14 (0.56, 2.29), 0.72 | 1.00 (0.42, 2.39), 1.00 |
| Age group | |||||
| Adults (1) | 1.08 (0.63, 1.85), 0.78 | 1.04 (0.43, 2.51), 0.94 | 1.27 (0.49,3.30), 0.63 | 1.14 (0.56, 2.29), 0.72 | 1.00 (0.42, 2.39), 1.00 |
| AMELX rs2106416 | |||||
| Ethnicity | |||||
| Caucasian (2) | 1.25 (0.77, 2.03), 0.37, 30, 0.23 | 1.83 (0.47, 7.06), 0.38, 40, 0.20 | 1.20 (0.65, 2.22), 0.56, 0, 0.54 | 1.25 (0.69, 2.27), 0.46, 0, 0.35 | 1.67 (0.44, 6.34), 0.45, 31, 0.23 |
| Age group | |||||
| Children (3) | 0.59 (0.16, 2.11), 0.41, 82, 0.003 | 1.83 (0.47, 7.06), 0.38, 40, 0.20 | 0.55 (0.13, 2.25), 0.40, 80, 0.006 | 0.59 (0.15, 2.31), 0.45, 79, 0.008 | 1.67 (0.44, 6.34), 0.45, 31, 0.23 |
Abbreviations: LTF Lactotransferrin, ENAM Enamelin, AMELX Amelogenin X, OR Odds ratio, CI Confidence interval; Ph, Pheterogeneity