Table 2.
Individual clinical, autopsy, and neuropathology details in white matter and gray matter of secondary progressive MS patients
| Case | MS 92 | MS 121 | MS 160 | MS 180 | MS 234 | MS 286 | MS 342 | MS 356 | MS 389 | MS 473 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex/age at death (years) | F/38 | F/49 | F/44 | F/44 | F/39 | M/45 | F/35 | F/45 | F/55 | F/39 | |
| Onset (years) | 21 | 35 | 28 | 26 | 24 | 29 | 30 | 29 | 28 | 27 | |
| Disease duration (years) | 17 | 14 | 16 | 18 | 15 | 16 | 5 | 16 | 27 | 12 | |
| Meningeal inflammation | + | – | + | + | – | + | – | – | – | – | |
| Perivascular infiltration | + | + | – | – | + | + | + | – | + | – | |
| IL-9+ in White matter | NAWM | – | + | – | – | – | + | – | – | – | – |
| Pre-active | – | – | – | – | ++ | ++ | – | – | – | – | |
| Active | – | – | – | – | – | – | ++ | ++ | ++ | ++ | |
| Chronic active | + | + | – | – | – | + | – | – | – | – | |
| Remyelination | – | – | + | – | + | – | – | – | – | – | |
| Inactive | – | – | – | – | – | + | – | – | – | – | |
| IL-9+ in Gray matter | NAGM | – | – | – | – | – | – | – | – | – | – |
| Pre-active | – | – | – | – | – | – | – | – | – | – | |
| Active | – | – | + | – | + | + | – | – | – | – | |
| Chronic active | – | + | + | – | + | + | – | – | – | – | |
| Remyelination | – | – | – | – | – | – | – | – | – | – | |
| Inactive | – | – | – | – | + | – | – | – | – | – | |
The degree of meningeal and perivascular inflammation was scored as −, absent; +, present; and ++, abundant. Similarly, the presence of IL-9 expressing (IL-9+) cells in the different types of lesions was scored as: −, absent; +, present; and ++, abundant. Tissues are classified as follows: normal appearing white matter (NAWM), normal appearing gray matter (NAGM), pre-active, chronic active, remyelination, and inactive