Table 2.

Acetylation regulation of mesenchymal stem cell differentiation into adipose cells.

Adipogenesis
Epigenetic mark/enzymatic function	Specific chromatin modifier	Targeted stem cell population	Differentiation	Refs.
Deacetylation
	HDAC3	3 T3-L1	Attenuates adipogenesis by binding to the master regulator PPARγ and attenuating PPARγ's capacity to drive gene expression	[56, 58]
	Sirt1	Mice bone marrow	Attenuates adipogenesis by binding to the master regulator PPARγ and repressing its target genes	[62, 63, 65–72]
			$\text{Sirt}1\downarrow \left\{\begin{array}{c}\text{Increase\hspace{0.17em}of\hspace{0.17em}acetylated\hspace{0.17em}PPAR}\gamma \to \text{increased\hspace{0.17em}C}/\text{EBP}\alpha \text{\hspace{0.17em}expression}\hfill \\ \begin{array}{c}\to \text{promoted\hspace{0.17em}adipogenesis}\hfill \\ \text{increase\hspace{0.17em}of\hspace{0.17em}acetylated\hspace{0.17em}Sox}9\to \text{reduction\hspace{0.17em}of\hspace{0.17em}collagen\hspace{0.17em}}2\alpha 1\hfill \end{array}\hfill \\ \to \text{impaired\hspace{0.17em}chondrogenic\hspace{0.17em}differentiation}\hfill \end{array}\right.$	[66]