Table 2.
The Da-Chai-Hu Decoction-related target information.
| UniProt ID | Target name | Gene name | Drug |
|---|---|---|---|
| P23219 | Prostaglandin G/H synthase 1 | PTGS1 | RB/SR/RPR/ATT/RRER/AFI/JF |
| P00742 | Coagulation factor Xa | F10 | RB/SR/ATT/AFI/RRER/ZOR/JF |
| P35354 | Prostaglandin G/H synthase 2 | PTGS2 | RB/SR/RPR/ATT/RRER/AFI/ZOR/JF |
| P07550 | Beta-2 adrenergic receptor | ADRB2 | RB/SR/ATT/AFI/JF |
| P08238 | Heat-shock protein HSP 90 | HSP90AB1 | RB/SR/RPR/ATT/RRER/AFI/JF |
| P00734 | Thrombin | F2 | RB/SR/AFI/RRER/JF |
| Q99527 | Estrogen receptor | GPER1 | RB/SR/RPR/RRER/AFI/ZOR/JF |
| P10275 | Androgen receptor | AR | RB/SR/RPR/ATT/AFI/RRER/JF |
| P08709 | Coagulation factor VII | F7 | RB/SR/ATT/AFI/RRER/JF |
| P22303 | Acetylcholinesterase | ACHE | RB/SR/AFI/JF |
| P11388 | DNA topoisomerase II | TOP2 | RB/SR/ATT/AFI/RRER/JF |
| Q92731 | Estrogen receptor-beta | ESTRB | RB/SR/AFI/RRER |
| P07477 | Trypsin-1 | PRSS1 | RB/SR/RPR/ATT/RRER/AFI/JF |
| Q15596 | Nuclear receptor coactivator 2 | NCOA2 | RB/SR/RPR/ATT/RRER/AFI/JF |
| P0DP23 | Calmodulin | CALM | RB/SR/RPR/ATT/RRER/AFI/ZOR/JF |
| P11229 | Muscarinic acetylcholine receptor M1 | CHRM1 | RB/SR/ATT/AFI/JF |
| P47869 | Gamma-aminobutyric-acid receptor alpha-2 subunit | GABRA2 | RB |
| P34903 | Gamma-aminobutyric-acid receptor alpha-3 subunit | GABRA3 | RB/JF |
| P08172 | Muscarinic acetylcholine receptor M2 | CHRM2 | RB/JF |
| Q16445 | Gamma-aminobutyric-acid receptor subunit alpha-6 | GABRA6 | RB |
| P35228 | Nitric oxide synthase, inducible | NOS2 | RB/SR/RPR/RRER/AFI/JF |
| Q14524 | Sodium channel protein type 5 subunit alpha | SCN5A | RB/SR/ATT/RRER/AFI/JF |
| P18031 | mRNA of protein-tyrosine phosphatase, nonreceptor type 1 | PTPN1 | RB/SR/AFI |
| P27487 | Dipeptidyl peptidase IV | DPP4 | RB/SR/RPR/ATT/RRER/AFI/JF |
| P01857 | Ig gamma-1 chain C region | IGHG1 | RB/SR/RRER |
| Q15788 | Nuclear receptor coactivator 1 | NCOA1 | RB/SR/RPR/ATT/AFI/JF |
| P37231 | Peroxisome proliferator-activated receptor-gamma | PPARG | RB/SR/AFI/JF |
| Q16539 | Mitogen-activated protein kinase 14 | MAPK14 | RB/SR/AFI |
| P49841 | Glycogen synthase kinase-3 beta | GSK3B | RB/SR/AFI |
| P24941 | Cell division protein kinase 2 | CDK2 | RB/SR/AFI |
| P48736 | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform | PIK3CG | RB/SR/RPR/ATT/RRER/AFI/JF |
| P17612 | mRNA of PKA catalytic subunit C-alpha | PRKACA | RB/SR/RPR/ATT/RRER/AFI/JF |
| P11309 | Proto-oncogene serine/threonine-protein kinase Pim-1 | PIM1 | RB/AFI |
| P20248 | Cyclin-A2 | CCNA2 | RB |
| P11217 | Glycogen phosphorylase, muscle form | PYGM | RB/SR/AFI |
| Q03181 | Peroxisome proliferator-activated receptor delta | PPARD | RB/SR/RRER |
| O14757 | Serine/threonine-protein kinase Chk1 | CHEK1 | RB/SR/AFI/RRER |
| P15121 | Aldose reductase | AKR1B1 | RB/RRER/JF |
| P29474 | Nitric oxide synthase, endothelial | NOS3 | RB/SR/AFI/JF |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABRA1 | RB/SR/RPR/AFI/JF |
| P27338 | Amine oxidase (flavin-containing) B | MAOB | RB/SR/AFI/JF |
| P42262 | Glutamate receptor 2 | GRIA2 | RB |
| P47989 | Xanthine dehydrogenase/oxidase | XDH | RB/AFI/JF |
| P06401 | Progesterone receptor | PGR | RB/RPR |
| P23975 | Sodium-dependent noradrenaline transporter | SLC6A2 | RB/JF |
| P35368 | Alpha-1B adrenergic receptor | ADRA1B | RB/SR/ATT/AFI/JF |
| P10415 | Apoptosis regulator Bcl-2 | BCL2 | RB/SR/RPR/ATT/AFI/JF |
| P01375 | Tumor necrosis factor | TNF | RB/SR/AFI/RRER/JF |
| P05412 | Transcription factor AP-1 | JUN | RB/SR/AFI/RRER/JF |
| P45983 | Mitogen-activated protein kinase 8 | MAPK8 | RB/AFI |
| P03956 | Interstitial collagenase | MMP1 | RB/SR/AFI/JF |
| P06493 | Cell division control protein 2 homolog | CDC2 | RB/SR/RPR/ATT/RRER/JF |
| P09601 | Heme oxygenase 1 | HMOX1 | RB/AFI/JF |
| P08684 | Cytochrome P450 3A4 | CYP3A4 | RB/JF |
| P05177 | Cytochrome P450 1A2 | CYP1A2 | RB/SR/JF |
| P16581 | E-selectin | SELE | RB/JF |
| P19320 | Vascular cell adhesion protein 1 | VCAM1 | RB/JF |
| P09917 | Arachidonate 5-lipoxygenase | ALOX5 | RB/JF |
| P09211 | Glutathione S-transferase P | GSTP1 | RB/RPR/AFI/JF |
| P35869 | Aryl hydrocarbon receptor | AHR | RB/SR/RPR/ATT/JF |
| P06213 | Insulin receptor | INSR | RB/AFI/JF |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | PPP3CA | RB |
| P09488 | Glutathione S-transferase Mu 1 | GSTM1 | RB/RPR/JF |
| P28161 | Glutathione S-transferase Mu 2 | GSTM2 | RB/RPR/JF |
| P42330 | Aldo-keto reductase family 1 member C3 | AKR1C3 | RB |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH2 | RB/SR/ATT/AFI/JF |
| P08254 | Stromelysin-1 | MMP3 | RB/JF |
| P19793 | Retinoic acid receptor RXR-alpha | RXRA | RB/SR/ATT/AFI/JF |
| P00533 | Epidermal growth factor receptor | EGFR | RB/AFI/JF |
| P15692 | Vascular endothelial growth factor A | VEGFA | RB/SR/ATT/RRER/AFI/JF |
| P00749 | Urokinase-type plasminogen activator | PLAU | RB/JF |
| P08253 | 72 kDa type IV collagenase | MMP2 | RB/RPR/AFI/JF |
| P28482 | Mitogen-activated protein kinase 1 | MAPK1 | RB/SR/AFI/JF |
| P01133 | Proepidermal growth factor | EGF | RB/JF |
| P06400 | Retinoblastoma-associated protein | RB1 | RB/AFI/JF |
| P05231 | Interleukin-6 | IL6 | RB/SR/AFI/JF |
| P04637 | Cellular tumor antigen p53 | TP53 | RB/SR/RPR/ATT/RRER/AFI/JF |
| P16435 | NADPH-cytochrome P450 reductase | POR | RB/JF |
| P11926 | Ornithine decarboxylase | ODC1 | RB/JF |
| P11387 | DNA topoisomerase 1 | TOP1 | RB/AFI/JF |
| P00441 | Superoxide dismutase (Cu-Zn) | SOD1 | RB/AFI/JF |
| P11021 | 78 kDa glucose-regulated protein | HSPA5 | RB/JF |
| Q13085 | Acetyl-CoA carboxylase 1 | ACACA | RB/JF |
| P13726 | Tissue factor | F3 | RB/JF |
| P17302 | Gap junction alpha-1 protein | GJA1 | RB/JF |
| P01584 | Interleukin-1 beta | IL1B | RB/RRER/JF |
| Q99616 | C-C motif chemokine 2 | CCL13 | RB/SR/JF |
| P43115 | Prostaglandin E2 receptor EP3 subtype | PTGER3 | RB/SR/JF |
| P49888 | Estrogen sulfotransferase | SULT1E1 | RB/SR/JF |
| O43451 | Maltase-glucoamylase, intestinal | MGAM | RB/SR/JF |
| P60568 | Interleukin-2 | IL2 | RB/AFI/JF |
| P00750 | Tissue-type plasminogen activator | PLAT | RB/JF |
| P07204 | Thrombomodulin | THBD | RB/JF |
| P02452 | Collagen alpha-1(I) chain | COL1A1 | RB/JF |
| P01579 | Interferon-gamma | IFNG | RB/AFI/JF |
| P05164 | Myeloperoxidase | MPO | RB/SR/RPR/ATT/JF |
| P15559 | NAD(P)H dehydrogenase [quinone] 1 | NQO1 | RB/JF |
| P02461 | Collagen alpha-1(III) chain | COL3A1 | RB/JF |
| P15309 | Prostatic acid phosphatase | ACPP | RB/JF |
| P07339 | Cathepsin D | CTSD | RB/JF |
| P27169 | Serum paraoxonase/arylesterase 1 | PON1 | RB/JF |
| Q9Y233 | cAMP and cAMP-inhibited cGMP 3′,5′-cyclic phosphodiesterase 10A | PDE10A | SR/ATT/JF |
| Q12791 | Calcium-activated potassium channel subunit alpha 1 | KCNMA1 | SR/AFI |
| P35968 | Vascular endothelial growth factor receptor 2 | KDR | SR/RRER/JF |
| P54289 | Voltage-dependent calcium channel subunit alpha-2/delta-1 | CACNA2D1 | SR |
| Q14432 | CGMP-inhibited 3′,5′-cyclic phosphodiesterase A | PDE3A | SR/RPR/ATT/AFI/JF |
| P61925 | cAMP-dependent protein kinase inhibitor alpha | PKIA | SR/RRER |
| P50613 | Cell division protein kinase 7 | CDK7 | SR |
| P11712 | Cytochrome P450 2C9 | CYP2C9 | SR |
| P99999 | Cytochrome c | CYCS | SR/RPR/ATT |
| Q9GZT9 | Egl nine homolog 1 | EGLN1 | SR/RPR/ATT |
| P00918 | Carbonic anhydrase II | CA2 | SR/AFI/ATT |
| P36544 | Neuronal acetylcholine receptor protein, alpha-7 chain | CHRNA7 | SR/JF |
| P49327 | Fatty acid synthase | FASN | SR/AFI/RRER/JF |
| P21728 | Dopamine D1 receptor | DRD1 | SR/ATT/JF |
| P20309 | Muscarinic acetylcholine receptor M3 | CHRM3 | SR/ATT/JF |
| P35348 | Alpha-1A adrenergic receptor | ADRA1A | SR/JF |
| Q01959 | Sodium-dependent dopamine transporter | SLC6A3 | SR/JF |
| P31645 | Sodium-dependent serotonin transporter | SLC6A4 | SR/ATT/JF |
| P08263 | Glutathione S-transferase A1 | GSTA1 | RPR |
| P09210 | Glutathione S-transferase A2 | GSTA2 | RPR |
| P08588 | Beta-1 adrenergic receptor | ADRB1 | ATT |
| P08912 | Muscarinic acetylcholine receptor M5 | CHRM5 | ATT/JF |
| P46098 | 5-Hydroxytryptamine receptor 3A | HTR3A | ATT/JF |
| P18825 | Alpha-2C adrenergic receptor | ADRA2C | ATT/AFI/JF |
| P08173 | Muscarinic acetylcholine receptor M4 | CHRM4 | ATT/JF |
| P41143 | Delta-type opioid receptor | OPRD1 | ATT/JF |
| P28223 | 5-Hydroxytryptamine 2A receptor | HTR2A | ATT/JF |
| P28335 | 5-Hydroxytryptamine 2C receptor | HTR2C | ATT/JF |
| P25100 | Alpha-1D adrenergic receptor | ADRA1D | ATT/JF |
| P35372 | Mu-type opioid receptor | OPRM1 | ATT/JF |
| P28702 | Retinoic acid receptor RXR-beta | RXRB | ATT |
| P00491 | Purine nucleoside phosphorylase | PNP | ATT |
| P47712 | Cytosolic phospholipase A2 | PLA2G4A | AFI |
| Q09428 | Sulfonylurea receptor 1 | ABCC8 | AFI |
| P56817 | Beta-secretase | BACE1 | AFI |
| P11802 | Cell division protein kinase 4 | CDK4 | AFI |
| P05067 | Amyloid beta A4 protein | APP | AFI |
| P55210 | Caspase-7 | CASP7 | AFI |
| P08581 | Hepatocyte growth factor receptor | MET | AFI |
| P27361 | Mitogen-activated protein kinase 3 | MAPK3 | AFI |
| P01130 | Low-density lipoprotein receptor | LDLR | AFI |
| P04040 | Catalase | CAT | AFI/JF |
| P04035 | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | AFI |
| P00390 | Glutathione reductase, mitochondrial | GSR | AFI |
| P33527 | Multidrug resistance-associated protein 1 | ABCC1 | AFI |
| Q04828 | Aldo-keto reductase family 1 member C1 | AKR1C1 | AFI |
| P17174 | Aspartate aminotransferase, cytoplasmic | GOT1 | AFI |
| P80404 | 4-Aminobutyrate aminotransferase, mitochondrial | ABAT | AFI |
| P35610 | Sterol O-acyltransferase 1 | SOAT1 | AFI |
| Q13698 | Voltage-dependent L-type calcium channel subunit alpha-1S | CACNA1S | JF |
| P27815 | Type IV phosphodiesterase | PDE4A | JF |
| P08235 | Mineralocorticoid receptor | NR3C2 | JF |
| P21918 | D(1B) dopamine receptor | DRD5 | JF |
| P21917 | D(4) dopamine receptor | DRD4 | JF |
| P18089 | Alpha-2B adrenergic receptor | ADRA2B | JF |
| Q15822 | Neuronal acetylcholine receptor subunit alpha-2 | CHRNA2 | JF |
| P14416 | D(2) dopamine receptor | DRD2 | JF |
| P20813 | Cytochrome P450 2B6 | CYP2B6 | JF |
| P08913 | Alpha-2A adrenergic receptor | ADRA2A | JF |
| O75469 | Pregnane X receptor | NR1I2 | AFI |