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The Th2-mediated reparative phase of MIRS. N2 neutrophils and M2 macrophages both produce high levels of IL-10 to dampen N1, Ly6Chi, and M1-mediated degradation of tissue integrity. Also, M2 macrophages induce Th2 and Treg differentiation, while both suppress Th1 development, and Tregs thwart Th2 cells. M2 differentiation is possible by phagocytosis of the neutrophil apoptotic bodies. M2 and Treg cells mediate tissue repair.
