Table 3.

Cox proportional hazard ratios for the primary and secondary outcomes of the elderly and nonelderly patients with AKI.

Outcome	Crude	p	Model I†	p	Model II‡	p
	HR (95% CI)		HR (95% CI)		HR (95% CI)
28-day in-hospital mortality	0.51 (0.33–0.79)	0.0024	0.49 (0.30–0.81)	0.0062	0.87 (0.48–1.58)	0.65
28-day RRT requirement	0.99 (0.64–1.57)	0.99	0.91 (0.55–1.50)	0.70	1.99 (1.02–3.86)	0.042

^†Model I: adjusted for comorbidity (DM, HTn, CAD, or CKD); sex, weight, height, and baseline eGFR. ^‡Model II: Model I plus infection or sepsis, APACHE II score, diuretic use, and AKI stage. APACHE II, Acute Physiology and Chronic Health Evaluation II; AKI, acute kidney injury; CAD, coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; DM, any type of diabetes mellitus; HR, hazard ratio; HTn, hypertension; and RRT, renal replacement therapy.