Table 1.
Active compounds of Yixin Ningshen tablet in treating heart diseases.
| No | Compound name | Origin | Formula | Semistructure | Reference |
|---|---|---|---|---|---|
| 1 | d-mannuronic acid | Ren Shen | C6H10O7 | [H][C@]1(O)O[C@]([H])(C(O)=O)[C@@]([H])(O)[C@]([H])(O)[C@]1([H])O | [20] |
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| 2 | Spathulenol | Ren Shen | C15H24O | C[C@@]1(CC[C@@H]2[C@@H]1[C@H]3[C@H](C3(C)C)CCC2=C)O | [21] |
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| 3 | Ginsenoside-rg1 | Ren Shen | C42H72O14 | CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C)O)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C | [22] |
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| 4 | Malic acid | Ren Shen | C4H6O5 | C(C(CC(=O)O)O)(=O)O | [23] |
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| 5 | Succinic acid | Ren Shen | C4H6O4 | C(CCC(=O)O)(=O)O | [24] |
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| 6 | Putrescine | Ren Shen | C4H12N2 | NCCCCN | [25] |
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| 7 | Spermidine | Ren Shen | C7H19N3 | NCCCCNCCCN | [5] |
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| 8 | Spermine | Ren Shen | C10H26N4 | C(CCNCCCN)CNCCCN | [26] |
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| 9 | Panaxatriol | Ren Shen | C30H52O4 | C[C@@]1(CCCC(O1)(C)C)[C@H]2CC[C@@]3([C@@H]2[C@@H](C[C@H]4[C@]3(C[C@H]([C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)O)C)O)C | [27] |
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| 10 | Panaxadiol | Ren Shen | C30H52O3 | C[C@@]1(CCCC(O1)(C)C)[C@H]2CC[C@@]3([C@@H]2[C@@H](C[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)O)C | [28] |
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| 11 | Pseudoginsenoside f11 | Ren Shen | C42H72O14 | C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2O[C@H]3C[C@@]4([C@H](C[C@H]([C@H]5[C@]4(CC[C@@H]5[C@@]6(CC[C@@H](O6)C(C)(C)O)C)C)O)[C@@]7([C@@H]3C([C@H](CC7)O)(C)C)C)C)CO)O)O)O)O)O | [29] |
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| 12 | β-Caryophyllene | Ren Shen | C15H24 | C=C1CC/C=C(C)/CC[C@@]2([H])C(C)(C)C[C@]12[H] | [30] |
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| 13 | 20(S)-Protopanaxatriol | Ren Shen | C30H52O4 | CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O)C)O)C)O)C | [31] |
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| 14 | Ginsenoside-rd | Ren Shen | C48H82O18 | CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C | [32] |
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| 15 | Ginsenoside-rk3 | Ren Shen | C36H60O8 | CC(=CCCC(=C)[C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C)O)C)C | [33] |
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| 16 | Vanillic acid | Ren Shen | C8H8O4 | COC1=C(C=CC(=C1)C(=O)O)O | [34] |
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| 17 | p-Coumaric acid | Ren Shen; He Huan Hua | C9H8O3 | C1=CC(=CC=C1C=CC(=O)O)O | [35] |
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| 18 | Kaempferol | Ren Shen; He Huan Hua | C15H10O6 | O=C(C1=C(O)C=C(O)C=C1O2)C(O)=C2C3=CC=C(O)C=C3 | [36] |
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| 19 | Adenosine | Ren Shen | C10H13N5O4 | C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N | [37] |
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| 20 | Niacin | Ren Shen | C6H5NO2 | C1=CC(=CN=C1)C(=O)O | [38] |
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| 21 | 20(R)-Ginsenoside-rh2 | Ren Shen | C36H62O8 | CC(=CCC[C@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C)C)O)C)O)C | [39] |
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| 22 | Ginsenoside-Re | Ren Shen | C48H82O18 | C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2O[C@H]3C[C@@]4([C@H](C[C@H]([C@H]5[C@]4(CC[C@@H]5[C@](C)(CCC=C(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)O)[C@@]7([C@@H]3C([C@H](CC7)O)(C)C)C)C)CO)O)O)O)O)O | [40] |
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| 23 | Ginsenoside-rb3 | Ren Shen | C53H90O22 | CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)O)O)O)C | [41] |
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| 24 | Ginsenoside-rb1 | Ren Shen | C54H92O23 | CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)O)O)C | [42] |
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| 25 | Ginsenoside-rg3 | Ren Shen | C42H72O13 | CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)O)C | [43] |
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| 26 | Ginsenoside-rg5 | Ren Shen | C42H70O12 | CC(=CC/C=C(\C)/[C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)C | [44] |
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| 27 | Ginsenoside-rg2 | Ren Shen | C42H72O13 | CC/C(=C/CC[C@@](C)(C1CC[C@]2(C1[C@H](CC3C2C[C@H](C4[C@@]3(CCC(C4(C)C)O)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@@H]([C@H]([C@@H](O6)C)O)O)O)O)C)O)/C | [45] |
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| 28 | Ginsenoside-rh1 | Ren Shen | C36H62O9 | CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)O)C)O)C)O)C | [46] |
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| 29 | 20(S)-Protopanaxadiol | Ren Shen | C30H52O3 | CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)O)C)O)C | [47] |
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| 30 | Protopanaxatriol | Ren Shen | C30H52O4 | CC(=CCC[C@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O)C)O)C)O)C | [31] |
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| 31 | Vitamin b5 | Ren Shen | C9H17NO5 | CC(C)(CO)[C@H](C(=O)NCCC(=O)O)O | [48] |
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| 32 | Citric acid | Ren Shen | C26H29NO | C(C(=O)O)C(CC(=O)O)(C(=O)O)O | [23] |
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| 33 | Folic acid | Ren Shen | C19H19N7O6 | C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N | [49] |
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| 34 | β-Sitosterol | Ren Shen; Wu Wei Zi | C29H50O | CC[C@H](CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(C)C | [50] |
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| 35 | β-D-Glucan | Ling Zhi | C18H32O16 | C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OC2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O)CO)CO)O)O)O)O | [51] |
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| 36 | Ganoderic acid A | Ling Zhi | C30H44O7 | C[C@H](CC(=O)C[C@@H](C)C(=O)O)[C@H]1C[C@@H]([C@@]2([C@@]1(CC(=O)C3=C2[C@H](C[C@@H]4[C@@]3(CCC(=O)C4(C)C)C)O)C)C)O | [52] |
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| 37 | Ergosterol | Ling Zhi | C28H44O | C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3C2=CC=C4[C@@]3(CC[C@@H](C4)O)C)C | [53] |
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| 38 | Betaine | Ling Zhi | C5H11NO2 | C[N+](C)(C)CC([O-])=O | [54] |
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| 39 | Trehalose | Ling Zhi | C12H22O11 | C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O)O)O)O | [55] |
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| 40 | Cyanidin-3-glucoside | He Huan Hua | C21H21ClO11 | C1=CC(=C(C=C1C2=[O+]C3=CC(=CC(=C3C=C2O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O)O)O.[Cl-] | [56] |
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| 41 | Gallic acid | He Huan Hua | C7H6O5 | C1=C(C=C(C(=C1O)O)O)C(=O)O | [57] |
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| 42 | 5-Hydroxymethylfurfural | He Huan Hua | C6H6O3 | C1=C(OC(=C1)C=O)CO | [58] |
| 43 | Quercetin | He Huan Hua | C15H10O7 | C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O | [59] |
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| 44 | Uridine | He Huan Hua | C9H12N2O6 | C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O | [60] |
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| 45 | Rutin | He Huan Hua | C27H30O16 | C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O | [61] |
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| 46 | Linoleic acid | He Huan Hua | C18H32O2 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | [62] |
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| 47 | Formononetin | He Huan Hua | C16H12O4 | COC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)O | [63] |
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| 48 | Isoliquiritigenin | He Huan Hua | C15H12O4 | O=C(/C=C/C1=C/C=C(/O)C=C1)C=2C=CC(O)=CC=2O | [64] |
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| 49 | Rhamnetin | He Huan Hua | C16H12O7 | O=C2/C1=C(\O)C=C(C=C1O/C(=C2/O)C3=C/C=C(/O)C(O)=C3)OC | [65] |
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| 50 | Isorhamnetin | He Huan Hua | C16H12O7 | O=C2/C1=C(\O)C=C(O)C=C1O/C(=C2/O)C3=C/C=C(/O)C(=C3)OC | [66] |
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| 51 | Chrysoeriol | He Huan Hua | C16H12O6 | O=C2C=C(OC1=CC(O)=CC(O)=C12)C3=C/C=C(/O)C(=C3)OC | [67] |
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| 52 | Luteolin | He Huan Hua | C15H10O6 | O=C2C=C(OC1=CC(O)=CC(O)=C12)C3=C/C=C(/O)C(O)=C3 | [68] |
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| 53 | Apigenin | He Huan Hua | C15H10O5 | O=C2C=C(OC1=CC(O)=CC(O)=C12)C3=C/C=C(/O)C=C3 | [69] |
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| 54 | Taxifolin | He Huan Hua | C15H12O7 | C1=CC(=C(C=C1[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O | [70] |
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| 55 | Schisandrin B | Wu Wei Zi | C23H28O6 | CC1CC2=CC3=C(OCO3)C(OC)=C2C4=C(OC)C(OC)=C(OC)C=C4CC1C | [71] |
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| 56 | Schisanhenol | Wu Wei Zi | C23H30O6 | CC1CC2=CC(OC)=C(OC)C(O)=C2C3=C(OC)C(OC)=C(OC)C=C3CC1C | [72] |
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| 57 | Deoxyschizandrin | Wu Wei Zi | C24H32O6 | CC1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3CC1C)OC)OC)OC)OC)OC)OC | [73] |
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| 58 | Geraniol | Wu Wei Zi | C10H18O | CC(=CCC/C(=C\CO)/C)C | [74] |
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| 59 | Linalool | Wu Wei Zi; He Huan Hua | C10H18O | CC(=CCCC(C)(C=C)O)C | [75] |
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| 60 | Schisantherin A | Wu Wei Zi | C30H32O9 | O[C@]([C@@H](C)C1)(C)[C@@H](OC(C2=CC=CC=C2)=O)C3=CC(OC)=C(OC)C(OC)=C3C4=C1C=C5OCOC5=C4OC | [73] |
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| 61 | α-Terpineol | Wu Wei Zi | C10H18O | OC(C)(C)C1CC=C(C)CC1 | [76] |
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| 62 | Gomisin A | Wu Wei Zi | C23H28O7 | CC1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4CC1(C)O)OC)OC)OC)OC)OCO3 | [77] |